Antonio Pea

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The overall rate of inaccurate preoperative diagnoses in a tertiary care center with a broad experience in pancreatology approached 22%.

TL;DR: Three mechanisms underlying local progression in the remnant pancreas are identified: residual microscopic disease at the resection margin, intraparenchymal spread of neoplastic cells, leading to an anatomically separate but genetically related recurrence, and multifocal disease with genetically distinct lesions.

TL;DR: A higher prevalence of likely independent co-occurring IPMN and ductal adenocarcinoma than previously appreciated is demonstrated and has important implications for molecular risk stratification of patients with IPMN.

TL;DR: The findings recommend the consideration of ENE from the gross sampling to the histopathological evaluation, in perspectives to be validated and included in the oncologic staging.