Steven Newhouse

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: This Roadmap identifies the challenges of data sharing across borders and demonstrates that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.

TL;DR: The Grid Interoperation Now—Community Group of the Open Grid Forum—organizes and manages interoperation efforts among those production Grid infrastructures to reach the goal of a world-wide Grid vision on a technical level in the near future.

TL;DR: This study highlights the major impact of rare and common germline variants on mutational landscapes in cancer and inferred over a hundred polymorphic L1/LINE elements with somatic retrotransposition activity in cancer.

TL;DR: The International Cancer Genome Consortium’s Pan-Cancer Analysis of Whole Genomes (PCAWG) project aimed to categorize somatic and germline variations in both coding and non-coding regions in over 2,800 cancer patients to provide high-quality validated consensus variants for downstream analysis.