L
Lars Beckmann
Researcher at German Cancer Research Center
Publications - 45
Citations - 2137
Lars Beckmann is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Breast cancer & Single-nucleotide polymorphism. The author has an hindex of 23, co-authored 44 publications receiving 1996 citations. Previous affiliations of Lars Beckmann include New York University.
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Journal ArticleDOI
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Montserrat Garcia-Closas,Fergus J. Couch,Sara Lindström,Kyriaki Michailidou,Marjanka K. Schmidt,Mark N. Brook,Nick Orr,Suhn K. Rhie,Elio Riboli,Heather Spencer Feigelson,Loic Le Marchand,Julie E. Buring,Diana Eccles,Penelope Miron,Peter A. Fasching,Peter A. Fasching,Hiltrud Brauch,Hiltrud Brauch,Jenny Chang-Claude,Jane Carpenter,Andrew K. Godwin,Heli Nevanlinna,Graham G. Giles,Graham G. Giles,Angela Cox,John L. Hopper,Manjeet K. Bolla,Qin Wang,Joe Dennis,Ed Dicks,William J. Howat,Nils Schoof,Stig E. Bojesen,Stig E. Bojesen,Diether Lambrechts,Diether Lambrechts,Annegien Broeks,Irene L. Andrulis,Pascal Guénel,Pascal Guénel,Barbara Burwinkel,Barbara Burwinkel,Elinor J. Sawyer,Antoinette Hollestelle,Olivia Fletcher,Robert Winqvist,Hermann Brenner,Arto Mannermaa,Ute Hamann,Alfons Meindl,Annika Lindblom,Wei Zheng,Peter Devillee,Peter Devillee,Mark S. Goldberg,Jan Lubinski,Vessela N. Kristensen,Anthony J. Swerdlow,Hoda Anton-Culver,Thilo Dörk,Kenneth Muir,Kenneth Muir,Keitaro Matsuo,Anna H. Wu,Paolo Radice,Soo Hwang Teo,Xiao-Ou Shu,William Blot,Daehee Kang,Mikael Hartman,Suleeporn Sangrajrang,Chen-Yang Shen,Chen-Yang Shen,Melissa C. Southey,Daniel J. Park,Fleur Hammet,Jennifer Stone,Laura J. van't Veer,Emiel J. Th. Rutgers,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Julian Peto,Michael G. Schrauder,Arif B. Ekici,Matthias W. Beckmann,Isabel dos Santos Silva,Nichola Johnson,Helen R. Warren,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Federick Marme,Andreas Schneeweiss,Christof Sohn,Thérèse Truong,Thérèse Truong,Pierre Laurent-Puig,Pierre Kerbrat,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Roger L. Milne,Jose Ignacio Arias Perez,Primitiva Menéndez,Heiko Müller,Volker Arndt,Christa Stegmaier,Peter Lichtner,Magdalena Lochmann,Christina Justenhoven,Christina Justenhoven,Yon Ko,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Dario Greco,Tuomas Heikkinen,Hidemi Ito,Hiroji Iwata,Yasushi Yatabe,Natalia Antonenkova,Sara Margolin,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Rosemary L. Balleine,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Patrick Neven,Anne Sophie Dieudonne,Karin Leunen,Anja Rudolph,Stefan Nickels,Dieter Flesch-Janys,Paolo Peterlongo,Bernard Peissel,Loris Bernard,Janet E. Olson,Xianshu Wang,Kristen N. Stevens,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,Catriona McLean,Gerhard A. Coetzee,Ye Feng,Brian E. Henderson,Fredrick R. Schumacher,Natalia Bogdanova,Martine Dumont,Cheng Har Yip,Nur Aishah Taib,Ching-Yu Cheng,Martha J. Shrubsole,Jirong Long,Katri Pylkäs,Arja Jukkola-Vuorinen,Saila Kauppila,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,R.A.E.M. Tollenaar,Caroline M. Seynaeve,Mieke Kriege,Maartje J. Hooning,Ans M.W. van den Ouweland,Carolien H.M. van Deurzen,Wei Lu,Yu Tang Gao,Hui Cai,Sabapathy P. Balasubramanian,Simon S. Cross,Malcolm W.R. Reed,Lisa B. Signorello,Qiuyin Cai,Mitul Shah,Hui Miao,Ching Wan Chan,Kee Seng Chia,Anna Jakubowska,Katarzyna Jaworska,Katarzyna Durda,Chia-Ni Hsiung,Pei Ei Wu,Jyh Cherng Yu,Alan Ashworth,Michael Jones,Daniel C. Tessier,Anna González-Neira,Guillermo Pita,M. Rosario Alonso,Daniel Vincent,Francois Bacot,Christine B. Ambrosone,Elisa V. Bandera,Esther M. John,Esther M. John,Gary K. Chen,Jennifer J. Hu,Jorge L. Rodriguez-Gil,Leslie Bernstein,Michael F. Press,Regina G. Ziegler,Robert M. Millikan,Sandra Deming-Halverson,Sarah J. Nyante,Sue A. Ingles,Quinten Waisfisz,Helen Tsimiklis,Enes Makalic,Daniel F. Schmidt,Minh Bui,Lorna Gibson,Bertram Müller-Myhsok,Rita K. Schmutzler,Rebecca Hein,Rebecca Hein,Norbert Dahmen,Lars Beckmann,Kirsimari Aaltonen,Kamila Czene,Astrid Irwanto,Jianjun Liu,Clare Turnbull,Nazneen Rahman,Hanne Meijers-Heijboer,André G. Uitterlinden,Fernando Rivadeneira,Curtis Olswold,Susan L. Slager,Robert Pilarski,Foluso O. Ademuyiwa,Irene Konstantopoulou,Nicholas G. Martin,Grant W. Montgomery,Dennis J. Slamon,Claudia Rauh,Michael P. Lux,Sebastian M. Jud,Thomas Brüning,JoEllen Weaver,Priyanka Sharma,Harsh B. Pathak,William J. Tapper,Sue Gerty,Lorraine Durcan,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Rosario Tumino,Petra H.M. Peeters,Rudolf Kaaks,Daniele Campa,Federico Canzian,Elisabete Weiderpass,Mattias Johansson,Kay-Tee Khaw,Ruth C. Travis,Françoise Clavel-Chapelon,Françoise Clavel-Chapelon,Laurence N. Kolonel,Constance Chen,Andrew H. Beck,Susan E. Hankinson,Susan E. Hankinson,Christine D. Berg,Robert N. Hoover,Jolanta Lissowska,Jonine D. Figueroa,Daniel I. Chasman,Mia M. Gaudet,W. Ryan Diver,Walter C. Willett,David J. Hunter,Jacques Simard,Javier Benitez,Alison M. Dunning,Mark E. Sherman,Georgia Chenevix-Trench,Stephen J. Chanock,Per Hall,Paul D.P. Pharoah,Celine M. Vachon,Douglas F. Easton,Christopher A. Haiman,Peter Kraft +287 more
TL;DR: SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers.
Journal ArticleDOI
Gene-environment interactions for complex traits: Definitions, methodological requirements and challenges
Astrid Dempfle,André Scherag,André Scherag,Rebecca Hein,Lars Beckmann,Jenny Chang-Claude,Helmut Schäfer +6 more
TL;DR: This review discusses methodological issues involved in investigating gene–environment (G × E) interactions in genetic–epidemiological studies of complex diseases and their potential relevance for clinical application and attempts to clarify conceptual differences of the term ‘interaction’ in the statistical and biological sciences.
Journal ArticleDOI
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
Afshan Siddiq,Fergus J. Couch,Gary K. Chen,Sara Lindström,Diana Eccles,Robert C. Millikan,Kyriaki Michailidou,Daniel O. Stram,Lars Beckmann,Suhn K. Rhie,Christine B. Ambrosone,Kristiina Aittomäki,Pilar Amiano,Carmel Apicella,Laura Baglietto,Laura Baglietto,Elisa V. Bandera,Matthias W. Beckmann,Christine D. Berg,Leslie Bernstein,Carl Blomqvist,Hiltrud Brauch,Louise A. Brinton,Quang M. Bui,Julie E. Buring,Saundra S. Buys,Daniele Campa,Jane Carpenter,Daniel I. Chasman,Jenny Chang-Claude,Constance Chen,Françoise Clavel-Chapelon,Angela Cox,Simon S. Cross,Kamila Czene,Sandra L. Deming,Robert B. Diasio,W. Ryan Diver,Alison M. Dunning,Lorraine Durcan,Arif B. Ekici,Peter A. Fasching,Peter A. Fasching,Heather Spencer Feigelson,Laura Fejerman,Jonine D. Figueroa,Olivia Fletcher,Dieter Flesch-Janys,Mia M. Gaudet,S Gerty,Jorge L. Rodriguez-Gil,Graham G. Giles,Graham G. Giles,Carla H. van Gils,Andrew K. Godwin,Nikki Graham,Dario Greco,Per Hall,Susan E. Hankinson,Arndt Hartmann,Rebecca Hein,Judith Heinz,Robert N. Hoover,John L. Hopper,Jennifer J. Hu,Scott Huntsman,Sue A. Ingles,Astrid Irwanto,Claudine Isaacs,Kevin B. Jacobs,Esther M. John,Esther M. John,Christina Justenhoven,Rudolf Kaaks,Laurence N. Kolonel,Gerhard A. Coetzee,Mark Lathrop,Loic Le Marchand,Adam M. Lee,I-Min Lee,Timothy G. Lesnick,Peter Lichtner,Jianjun Liu,Eiliv Lund,Enes Makalic,Nicholas G. Martin,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Penelope Miron,Kristine R. Monroe,Grant W. Montgomery,Bertram Müller-Myhsok,Stefan Nickels,Sarah J. Nyante,Curtis Olswold,Kim Overvad,Domenico Palli,Daniel J. Park,Julie R. Palmer,Harsh B. Pathak,Julian Peto,Paul D.P. Pharoah,Nazneen Rahman,Fernando Rivadeneira,Daniel F. Schmidt,Rita K. Schmutzler,Susan L. Slager,Melissa C. Southey,Kristen N. Stevens,Hans-Peter Sinn,Michael F. Press,Eric A. Ross,Elio Riboli,Paul M. Ridker,Fredrick R. Schumacher,Gianluca Severi,Gianluca Severi,Isabel dos Santos Silva,Jennifer Stone,Malin Sund,William J. Tapper,Michael J. Thun,Ruth C. Travis,Clare Turnbull,André G. Uitterlinden,Quinten Waisfisz,Xianshu Wang,Zhaoming Wang,JoEllen Weaver,Rüdiger Schulz-Wendtland,Lynne R. Wilkens,David Van Den Berg,Wei Zheng,Regina G. Ziegler,Elad Ziv,Heli Nevanlinna,Douglas F. Easton,David J. Hunter,Brian E. Henderson,Stephen J. Chanock,Montserrat Garcia-Closas,Peter Kraft,Christopher A. Haiman,Celine M. Vachon +144 more
TL;DR: The largest meta-analysis of ER-negative disease to date, comprising 4754 ER- negative cases and 31 663 controls from three GWAS, identified two novel loci for breast cancer at 20q11 and 6q14 and confirmed three known loci associated with ER- Negative, triple negative and ER-positive breast cancer.
Journal ArticleDOI
Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk.
TL;DR: An effect of polymorphisms in factors of the innate immune response in the aetiology of some lymphoma subtypes is suggested.
Journal ArticleDOI
Matrix Metalloproteinase 1 (MMP1) Is Associated with Early-Onset Lung Cancer
Wiebke Sauter,Albert Rosenberger,Lars Beckmann,Silke Kropp,Kirstin Mittelstrass,Maria Timofeeva,Gabi Wölke,Angelika Steinwachs,Daniela Scheiner,Eckart Meese,Gerhard W. Sybrecht,Florian Kronenberg,Hendrik Dienemann,Jenny Chang-Claude,Thomas Illig,Heinz-Erich Wichmann,Heike Bickeböller,Angela Risch +17 more
TL;DR: MMP1 was identified to be associated with an increased risk for lung cancer, which was modified by smoking, and haplotype analysis supported these findings, especially for subgroups with high smoking intensity.