S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Layer dependent role of collagen recruitment during loading of the rat bladder wall
Fangzhou Cheng,Anne M. Robertson,Lori A. Birder,F. Aura Kullmann,Jack Hornsby,Paul N. Watton,Simon C. Watkins +6 more
TL;DR: In this article, a custom biaxial mechanical testing system compatible with multiphoton microscopy was used to directly measure the layer dependent collagen fiber recruitment in bladder tissue from 9 male Fischer rats (4 adult and 5 aged).
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Adenovirus-mediated gene therapy to liver grafts: successful gene transfer by donor pretreatment.
Yoshihito Takahashi,David A. Geller,Andrea Gambotto,Simon C. Watkins,John J. Fung,Noriko Murase +5 more
TL;DR: Gene transfer by donor pretreatment with AdEGFP induces early and efficient gene transduction to liver grafts compared with back-table delivery with CT, and provides early transgene expression in liver grafting that potentially could be used to deliver genes to decrease preservation injury or rejection.
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Dynamic Na+-H+ Exchanger Regulatory Factor-1 Association and Dissociation Regulate Parathyroid Hormone Receptor Trafficking at Membrane Microdomains
TL;DR: The ability of NHERF to interact dynamically with the PTHR and cognate adapter proteins regulates receptor trafficking and signaling in a spatially and temporally coordinated manner.
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Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model.
Shruti M. Phadke,Kazi Islam,Berthony Deslouches,Sunil A. Kapoor,Donna B. Stolz,Simon C. Watkins,Ronald C. Montelaro,Joseph M. Pilewski,Timothy A. Mietzner +8 more
TL;DR: Overall, eLLPs are selectively toxic to bacteria and may be useful against CF airway infections.
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Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
Jing Zhao,Jing Zhao,Lei Zhang,Xiaodong Mu,Christelle Doebelin,William Nguyen,Callen T. Wallace,Daniel P. Reay,Sara J. McGowan,Lana Corbo,Paula R. Clemens,Gabriela Mustata Wilson,Simon C. Watkins,Laura A. Solt,Michael D. Cameron,Johnny Huard,Laura J. Niedernhofer,Theodore M. Kamenecka,Paul D. Robbins +18 more
TL;DR: Chronic treatment of a mouse model of Duchenne muscular dystrophy with SR12343 and SR12460 attenuated inflammatory infiltration, necrosis and muscle degeneration, demonstrating that these small-molecule NBD mimetics are potential therapeutics for inflammatory and degenerative diseases.