S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Improved spatial resolution of matrix-assisted laser desorption/ionization imaging of lipids in the brain by alkylated derivatives of 2,5-dihydroxybenzoic acid.
Detcho A. Stoyanovsky,Louis J. Sparvero,Andrew A. Amoscato,Rong-Rong He,Rong-Rong He,Simon C. Watkins,Bruce R. Pitt,Hülya Bayır,Valerian E. Kagan +8 more
TL;DR: In this article, the authors developed improved matrices for lipid analysis based on structural modification of the commonly used matrix 2,5-dihydroxybenzoic acid (DHB).
Journal ArticleDOI
IL-6 adsorption dynamics in hemoadsorption beads studied using confocal laser scanning microscopy.
TL;DR: An extracorporeal hemoadsorption device to remove cytokines from the blood using biocompatible, polymer sorbent beads is developed, and development of smaller beads may accelerate cytokine adsorption by maximizing available surface area per bead mass.
Journal Article
Complementation of defective leucine decarboxylation in fibroblasts from a maple syrup urine disease patient by retrovirus-mediated gene transfer.
Gunhild M. Mueller,L R McKenzie,Gregg E. Homanics,Simon C. Watkins,Paul D. Robbins,Harbhajan S Paul +5 more
TL;DR: The successful use of retroviral gene transfer to restore leucine decarboxylation activity in fibroblasts derived from a MSUD patient containing a mutation in the E2 subunit demonstrates complementation of a phenotype resulting from a gene defect whose product is a part of a multienzyme complex.
Journal ArticleDOI
Are mitochondrial reactive oxygen species required for autophagy
Jianfei Jiang,Akihiro Maeda,Jing Ji,Catherine J. Baty,Simon C. Watkins,Joel S. Greenberger,Valerian E. Kagan +6 more
TL;DR: It is concluded that mitochondrial ROS are not required for the induction of autophagy, and both electron transport and ROS generation were completely disrupted in mitochondria DNA-deficient HeLa1.2 cells.
Journal ArticleDOI
P-selectin–deficient mice to study pathophysiology of sickle cell disease
Margaret F. Bennewitz,Egemen Tutuncuoglu,Shweta Gudapati,Tomasz Brzoska,Simon C. Watkins,Satdarshan P.S. Monga,Tirthadipa Pradhan-Sundd,Prithu Sundd +7 more
TL;DR: These findings suggest that SCD mice genetically deficient in P-selectin would be protected from vaso-occlusion, and introduce the first SCd mice genetically lacking P- selectin in hematopoietic and nonhematopoetic compartments.