S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Regulated recycling of mutant CFTR is partially restored by pharmacological treatment
TL;DR: Taken together, corrector treatment redirects F508del trafficking from a degradative pathway to a regulated recycling route, and proteins that mediate this process become potential targets for improving the efficacy of current and future correctors.
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Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis.
Thomas J. Richards,Chunghyun Park,Yiliang Chen,Yiliang Chen,Kevin F. Gibson,Y. Peter Di,Annie Pardo,Simon C. Watkins,Augustine M.K. Choi,Augustine M.K. Choi,Moisés Selman,Joseph M. Pilewski,Naftali Kaminski,Yingze Zhang +13 more
TL;DR: Evidence for genetic correlation of plasma levels and promoter polymorphisms (rs11568818 and rs11568819) of MMP7 in a well-characterized IPF cohort is reported and it is suggested that increased sensitivity of the polymorphic MMP 7 promoter to FOXA2 provides one of the genetic bases for the upregulation of M MP7 in IPF.
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A cascade of ER exit site assembly that is regulated by p125A and lipid signals.
TL;DR: Lipid recognition by the SAM–DDHD module was used to stabilize membrane association and regulate the spatial segregation of COPII from Sec16A, nucleating the coat at ERES for ER exit.
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Pure endotoxin does not pass across the intestinal epithelium in vitro.
Ronnie Benoit,Stephen Rowe,Simon C. Watkins,Patricia Boyle,Melissa Garrett,Sean Alber,Justin Wiener,Marc I. Rowe,Henri R. Ford +8 more
TL;DR: It is concluded that pure LPS does not pass across the intestinal mucosa in vitro, due, at least in part, to the release of bacterial cell wall fragments containing LPS from killed bacteria that had previously translocated.
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Nucleophilic distribution of metallothionein in human tumor cells.
TL;DR: The ability ofMT to accumulate in subcellular compartments against its concentration gradient may be important in the capacity of MT to supply Zn or other metals to target sites within the cell.