S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans.
Xiaopeng Zhang,Sean Alber,Simon C. Watkins,Patrick M. Kochanek,Donald W. Marion,Steven H. Graham,Robert S. B. Clark +6 more
TL;DR: Data show that caspase-7 and its cleavage product are increased in human brain after TBI in many central nervous system, as well as noncentral nervousSystem, cell types, and may play a role in the glial and inflammatory responses, and possibly neuronal death, after TBO in humans.
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Limitations of nlsβ‐galactosidase as a marker for studying myogenic lineage or the efficacy of myoblast transfer
TL;DR: The extent to which nlsβ‐gal is translocated in hybrid myofibers, both in vitro and in vivo, is reexamined and the extent toWhich one can rely on histochemistry to distinguish encoding from noncoding nuclei in these my ofibers is evaluated.
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Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking
Lydia A. Perkins,Qi Yan,Brigitte F. Schmidt,Dmytro Kolodieznyi,Saumya Saurabh,Mads Breum Larsen,Simon C. Watkins,Laura Kremer,Marcel P. Bruchez +8 more
TL;DR: Quantitative profiling of the endocytosis and recycling of tagged β2-adrenergic receptor (B2AR) at a single-vesicle level revealed differences among B2AR agonists, consistent with more detailed pharmacological profiling.
Proceedings ArticleDOI
The Effect of Changes in Ambient and Coolant Radiator Inlet Temperatures and Coolant Flowrate on Specific Dissipation
TL;DR: In this paper, a theoretical model for the calculation of Specific Dissipation (SD) was developed based on themodel, and the effect of ambient and coolant radiator inlet temperature variation on SD has been predicted.
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Influence of Large-Scale Freestream Turbulence on the Performance of a Thin Airfoil
TL;DR: In this paper, the combined influences of low Reynolds number effects and the high levels of freestream turbulence, present within the atmospheric boundary layer, make it difficult to control/fly outdoors.