S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
SARS-CoV-2 Viremia is Associated with COVID-19 Severity and Predicts Clinical Outcomes.
Jana L. Jacobs,William Bain,Asma Naqvi,Brittany Staines,Priscila M. S. Castanha,Haopu Yang,Haopu Yang,Valerie F. Boltz,Simon M. Barratt-Boyes,Ernesto T. A. Marques,Stephanie L. Mitchell,Barbara Methé,Tolani F. Olonisakin,Ghady Haidar,Thomas W. Burke,Elizabeth Petzold,Thomas N. Denny,Christopher W. Woods,Christopher W. Woods,Bryan J. McVerry,Janet S. Lee,Simon C. Watkins,Claudette M. St. Croix,Alison Morris,Mary F. Kearney,Mark S. Ladinsky,Pamela J. Bjorkman,Georgios D Kitsios,John W. Mellors +28 more
TL;DR: In this article, SARS-CoV-2 vRNA was detected in plasma of 100%, 52.6%, and 11.1% of ICU, non-ICU, and outpatients respectively.
Journal ArticleDOI
Golgi-associated Maturation of Very Low Density Lipoproteins Involves Conformational Changes in Apolipoprotein B, but Is Not Dependent on Apolipoprotein E
Viktoria Gusarova,Jeongmin Seo,Mara Sullivan,Simon C. Watkins,Jeffrey L. Brodsky,Edward A. Fisher +5 more
TL;DR: It is concluded that VLDL maturation in the Golgi involves apoB conformational changes and that the expansion of the lipoprotein does not require apoE; rather, the increase in V LDL surface area favors apo E binding.
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EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo.
Itziar Pinilla-Macua,Alexandre Grassart,Umamaheswar Duvvuri,Simon C. Watkins,Alexander Sorkin +4 more
TL;DR: The data suggest that a small pool of active EGFRs is sufficient to drive tumorigenesis by signaling primarily through the Ras-MAPK pathway.
Journal Article
Retrovirus-mediated gene transfer in lungs of living fetal sheep
Bruce R. Pitt,Margaret A. Schwarz,Joseph M. Pilewski,Don K. Nakayama,Gunhild M. Mueller,Paul D. Robbins,Simon C. Watkins,Kurt H. Albertine,Richard D. Bland +8 more
TL;DR: Transgene expression in the airways of fetal lamb lungs, 2-3 weeks after injection of Moloney murine leukemia retrovirus based vectors containing cDNA for beta-galactosidase or human interleukin receptor antagonist protein (IRAP) is demonstrated for the first time.
Journal ArticleDOI
Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models.
Eric N. Anderson,Lauren Gochenaur,Aditi Singh,Rogan A. Grant,Krishani Patel,Simon C. Watkins,Jane Y. Wu,Udai Bhan Pandey +7 more
TL;DR: It is demonstrated that trauma can induce stress granules formation in vivo and might enhance neurodegenerative phenotypes in the fly models of ALS.