S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
Papers
More filters
Journal ArticleDOI
Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver
Kathryn E. Wack,Kathryn E. Wack,Mark A. Ross,Vasthy Zegarra,Vasthy Zegarra,Laura R. Sysko,Simon C. Watkins,Donna B. Stolz +7 more
TL;DR: The data reveal that SEC are dynamic regulators of porosity that respond rapidly and locally to environmental zonal stimuli during liver regeneration.
Journal ArticleDOI
Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.
Anna A. Shvedova,Alexandr A. Kapralov,Wei Hong Feng,Elena R. Kisin,Ashley R. Murray,Robert R. Mercer,Claudette M. St. Croix,Megan A. Lang,Simon C. Watkins,Nagarjun V. Konduru,Brett L. Allen,Jennifer Conroy,Gregg P. Kotchey,Bashir M. Mohamed,Aidan D. Meade,Yuri Volkov,Alexander Star,Bengt Fadeel,Valerian E. Kagan +18 more
TL;DR: Results provide direct evidence for the participation of MPO – one of the key-orchestrators of inflammatory response – in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of nanomaterials through genetic or pharmacological manipulations.
Journal ArticleDOI
Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.
Margaret A. Schwarz,John S. Lazo,Jack C. Yalowich,Ian J. Reynolds,Valerian E. Kagan,Vladimir A. Tyurin,Young Myeong Kim,Simon C. Watkins,Bruce R. Pitt +8 more
TL;DR: Data provide direct support for an antioxidant role for MT, since physiologically relevant elevations in cytoplasmic MT interfere with tBH-induced cytotoxic peroxidation.
Journal ArticleDOI
An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury
Cliff J. Luke,Stephen C. Pak,Yuko S. Askew,Terra L. Naviglia,David J. Askew,Shila M. Nobar,Anne C. Vetica,Olivia S. Long,Simon C. Watkins,Donna B. Stolz,Robert Barstead,Gary Moulder,Dieter Brömme,Gary A. Silverman,Gary A. Silverman +14 more
TL;DR: It is suggested that multiple noxious stimuli converge upon a peptidase-driven, core stress response pathway that, in the absence of serpin regulation, triggers a lysosomal-dependent necrotic cell death routine.
Journal ArticleDOI
The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells
TL;DR: This work has identified a new mechanism by which potentially immunogenic glycoprotein tumor Ags, such as MUC1, fail to stimulate strong immune responses, and shows that a 140-aa-long synthetic peptide is very efficiently processed by dendritic cells.