S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
Papers
More filters
Journal ArticleDOI
HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
Lauren B. Kinner-Bibeau,Abigail L. Sedlacek,Michelle N. Messmer,Simon C. Watkins,Robert J. Binder +4 more
TL;DR: In this paper, the authors defined a CD91-dependent mechanism through which gp96 controls dichotomous immune responses relevant to the therapy of cancer and auto-immunity, and showed that gp96 preferentially engages conventional and plasmacytoid dendritic cells under low and high doses, respectively.
Journal ArticleDOI
Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca2+ in putative nociceptive glabrous skin neurons from the rat.
TL;DR: The results indicate that the paclitaxel-induced decrease in the duration of the evoked Ca2+ transient is due to both direct and indirect influences of mitochondria.
Journal ArticleDOI
Histochemical fibre typing and ultrastucture of the small fibres in duchenne muscular dystrophy
TL;DR: Watkins S. C. & Cullen M. J. (1985) Neuropathology and Applied Neurobiology 11, 447–460.
Journal ArticleDOI
Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells.
TL;DR: It is proposed that the ALI culture method can be widely adopted as a physiologically relevant model to study EBV pathogenesis in polarized nasal epithelial cells.
Journal ArticleDOI
Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner.
Zhou Zhong,Jiying Ning,Emerson A. Boggs,Sooin Jang,Sooin Jang,Callen T. Wallace,Cheryl A. Telmer,Marcel P. Bruchez,Jinwoo Ahn,Alan Engelman,Alan Engelman,Peijun Zhang,Simon C. Watkins,Zandrea Ambrose +13 more
TL;DR: In this article, the authors show that premature or too much binding of one human protein, cleavage and polyadenylation specificity factor 6 (CPSF6), disrupts the ability of the capsid to deliver the viral genome to the cell nucleus.