S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Dynamic changes in p27kip1 variant expression in activated lymphocytes
TL;DR: Results indicate that lymphocytes exiting from quiescence use several mechanisms to overcome the p27Kip1‐enforced cell cycle checkpoint, and that elimination of p27 is not required for cell cycle entry.
Proceedings ArticleDOI
Cyberinfrastructure of a Multi-Petabyte Microscopy Resource for Neuroscience Research
Kathy Benninger,Greg Hood,Derek Simmel,Luke Tuite,Arthur W. Wetzel,Alexander J. Ropelewski,Simon C. Watkins,Alan M. Watson,Marcel P. Bruchez +8 more
TL;DR: The Brain Image Library (BIL) serves the neuroscience community by providing a persistent repository for the massive amounts of data being generated and by offering brain researchers supercomputing-class processing and visualization capabilities for working with high-resolution brain image datasets.
Proceedings ArticleDOI
Pressure Fluctuations on Automotive Rear View Mirrors
TL;DR: In this article, the authors experimentally determine the fluctuating base pressure on a standard and modified mirror and find that increasing the length of the extension changed the pressure pattern across the face, and the over all magnitude of the fluctuations reduced with increasing length of extension.
Journal ArticleDOI
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity.
Sayan Ghosh,Haitao Liu,Meysam Yazdankhah,Nadezda A. Stepicheva,Peng Shang,Tanuja Vaidya,Stacey Hose,Urvi Gupta,Michael J. Calderon,Ming Wen Hu,Archana Padmanabhan Nair,Joseph Weiss,Christopher Scott Fitting,Imran Ahmed Bhutto,Santosh Gopi Krishna Gadde,Naveen Kumar Naik,Chaitra Jaydev,Gerard A. Lutty,James T. Handa,Ashwath Jayagopal,Jiang Qian,José-Alain Sahel,José-Alain Sahel,Dhivyaa Rajasundaram,Yuri V. Sergeev,J. Samuel Zigler,Swaminathan Sethu,Simon C. Watkins,Arkasubhra Ghosh,Debasish Sinha,Debasish Sinha +30 more
TL;DR: It is found that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in mice, suggesting the possibility that the interaction between βA 1-PTP1B may be targeted for diabetic Retinopathy.
Journal ArticleDOI
Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity.
Tatiana Sorkina,Mary Hongying Cheng,Tarique Rajasaheb Bagalkot,Callen T. Wallace,Simon C. Watkins,Ivet Bahar,Alexander Sorkin +6 more
TL;DR: In this article, small molecule-induced DAT oligomerization and endocytosis are investigated and shown to be favored by the inward-facing DAT conformation and involve interactions of four hydrophobic residues at the interface between transmembrane (TM) helices TM4 and TM9.