S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Adenovirus-Transduced Dendritic Cells Injected into Skin or Lymph Node Prime Potent Simian Immunodeficiency Virus-Specific T Cell Immunity in Monkeys
Kevin N. Brown,Wentao Gao,Sean Alber,Anita M. Trichel,Michael Murphey-Corb,Simon C. Watkins,Andrea Gambotto,Simon M. Barratt-Boyes +7 more
TL;DR: Interestingly, intradermal and intranodal injections generated a similar intensity and breadth of response, indicating that administration of Ag-expressing DC by either route may be equally effective at inducing immune responses.
Journal Article
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Cynthia A. Znati,Maury Rosenstein,Trevor D. McKee,Edward B. Brown,David P. Turner,William D. Bloomer,Simon C. Watkins,Rakesh K. Jain,Yves Boucher +8 more
TL;DR: It is shown that the interstitial diffusion of large molecules is significantly hindered in tumors with high collagen levels, and after irradiation, the decrease in K and increase in collagen type I levels could significantly hinder the convective movement and diffusion ofLarge therapeutic agents in tumors.
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The AP-2 Adaptor β2 Appendage Scaffolds Alternate Cargo Endocytosis
Peter A. Keyel,James R. Thieman,Robyn Roth,Elif Erkan,Eric T. Everett,Simon C. Watkins,John E. Heuser,Linton M. Traub +7 more
TL;DR: It is concluded that ARH and beta-arrestin depend on a privileged beta2 appendage site for proper cargo recruitment to clathrin bud sites.
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The Modulation of Hepatic Injury and Heat Shock Expression by Inhibition of Inducible Nitric Oxide Synthase After Hemorrhagic Shock
John M. Menezes,Chris Hierholzer,Simon C. Watkins,Timothy R. Billiar,Andrew B. Peitzman,Brian G. Harbrecht +5 more
TL;DR: Excessive NO production from iNOS contributes to shock-induced hepatic injury, and the data suggest HSP expression may reflect the degree of ischemic injury after hemorrhage.
Journal ArticleDOI
Physical and functional association of migfilin with cell-cell adhesions
Vasiliki Gkretsi,Yongjun Zhang,Yizeng Tu,Ka Chen,Donna B. Stolz,Yanqiang Yang,Simon C. Watkins,Chuanyue Wu +7 more
TL;DR: Migfilin is identified as a component of adherens junctions and an important role for migfilin in the organization of the cell-cell adhesion structure is suggested.