S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Sequential delivery of interferon-alpha gene and DCs to intracranial gliomas promotes an effective antitumor response
T Tsugawa,Naruo Kuwashima,Hidemitsu Sato,Wendy Fellows-Mayle,Jill E. Dusak,Kaori Okada,Glenn D. Papworth,Simon C. Watkins,Andrea Gambotto,Jun Yoshida,Ian F. Pollack,Hideho Okada +11 more
TL;DR: In vitro migration assays revealed the ability of DCs to migrate toward the tumor, suggesting that i.t. injected DCs migrate through the glioma, and this combination of gene therapy and cellular immunotherapy may be an effective future strategy for treating human gliomas.
Journal Article
Intercellular and Intracellular Events Following the MHC-Unrestricted TCR Recognition of a Tumor-Specific Peptide Epitope on the Epithelial Antigen MUC1
Julie Magarian-Blander,Julie Magarian-Blander,Pawel Ciborowski,Shyuan Hsia,Simon C. Watkins,Olivera J. Finn +5 more
TL;DR: MHC-unrestricted TCR triggering, therefore, involves similar intercellular and intracellular events that participate in the conventional, MHC-restricted Ag recognition.
Journal ArticleDOI
alpha-actinin-2 is a new component of the dystrophin-glycoprotein complex.
TL;DR: It is proposed that dystrophin forms lateral, multicontact association with actin and that binding of alpha-actinin-2 to the carboxyl-terminus of dystrophicin is the communication link between the integrins and the dystphin/dystroph in-glycoprotein complex.
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Caveolae-dependent and -independent uptake of albumin in cultured rodent pulmonary endothelial cells.
Hui-Hua Li,Jin Li,Karla J. Wasserloos,Callen T. Wallace,Mara G. Sullivan,Philip M. Bauer,Donna B. Stolz,Janet S. Lee,Simon C. Watkins,Claudette M. St. Croix,Bruce R. Pitt,Li-Ming Zhang +11 more
TL;DR: A portion of overall uptake in pulmonary endothelial cells is cav-1 insensitive and appears to involve clathrin-mediated endocytosis and macropinocytotic-like process, in addition to the well described caveolar-dependent pulmonary endothelium cell endocyTosis of albumin.
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Pharmacological Rescue of the Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Detected by Use of a Novel Fluorescence Platform
John P. Holleran,John P. Holleran,Matthew L. Glover,Kathryn W. Peters,Carol A. Bertrand,Simon C. Watkins,Jonathan W. Jarvik,Raymond A. Frizzell +7 more
TL;DR: A fluorescence detection platform using fluorogen-activating proteins (FAPs) is developed to directly detect FAP-CFTR trafficking to the cell surface using a cell-impermeant probe, indicating that this approach should be useful as a screening assay in diseases that impair protein trafficking toThe cell surface.