S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
iPSC-derived neurons from patients with POLG mutations exhibit decreased mitochondrial content and dendrite simplification.
Manish Verma,Lily Francis,Britney N. Lizama,Jason Callio,Gabriella Fricklas,Kent Z.Q. Wang,Brett A. Kaufman,Leonardo D'Aiuto,Donna B. Stolz,Simon C. Watkins,Vishwajit L. Nimgaonkar,Alejandro Soto-Gutierrez,Amy Goldstein,Charleen T. Chu +13 more
TL;DR: In this paper , the authors showed that mutations in the gene encoding the catalytic subunit of DNA polymerase gamma, resulting in clinical syndromes characterized by mitochondrial DNA depletion in affected tissues with variable organ involvement, such as intractable seizures, developmental delay, dementia and ataxia.
Book ChapterDOI
The Flow Environment of Road Vehicles in Winds and Traffic
TL;DR: In this paper, the effect of upstream vehicle wakes on the aerodynamic development of a new vehicle is examined, via wind-tunnel measurements of wakes of Ahmed bodies using dynamically calibrated multi-hole probes.
Journal ArticleDOI
LiverClear: A versatile protocol for mouse liver tissue clearing
Laura Molina,Yekaterina Krutsenko,Nathaniel E. C. Jenkins,Megan Smith,Junyan Tao,Travis B. Wheeler,Simon C. Watkins,Alan M. Watson,Satdarshan P.S. Monga +8 more
TL;DR: LiverClear as mentioned in this paper combines strategies from several previously published protocols for delipidation, decolorization, staining, and refractive index matching for liver tissue clearing, which is sufficiently versatile to allow clearing of healthy and diseased mouse liver followed by immunofluorescence staining and imaging.
Book ChapterDOI
CHAPTER 17 – Imaging dendritic cells: a primer
TL;DR: DCs are often best identified from other leukocytes using surface topology afforded by scanning electron microscopy (SEM), which allows the visualization of the membrane “veils” or “dendrites,” which readily distinguish DCs from other cell types.
Journal ArticleDOI
Combining Novel Probes and High Resolution Imaging to Dissect Mitochondrial Function in Living Systems
Karina A. Peña,Mads Breum Larsen,Mike Calderon,Michael Tsang,Simon C. Watkins,Marcel P. Bruchez,Claudette M. St. Croix +6 more
TL;DR: The combined use of novel genetically targeted probes and high resolution optical imaging technologies are described to explore mitochondrial metabolism, ROS generation and function/dysfunction in the context of the living zebrafish (Danio rerio).