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Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Epsin 1 is a Polyubiquitin‐Selective Clathrin‐Associated Sorting Protein
Matthew J. Hawryluk,Peter A. Keyel,Sanjay K. Mishra,Simon C. Watkins,John E. Heuser,Linton M. Traub +5 more
TL;DR: It is shown that endogenous epsin 1 is clearly an integral component of clathrin coats forming at the cell surface and is essentially absent from caveolin‐1‐containing structures under normal conditions.
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Memory CD4+ T Cells Are the Earliest Detectable Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells in the Female Genital Mucosal Tissue during HIV-1 Transmission in an Organ Culture System
Phalguni Gupta,Kelly B. Collins,Deena Ratner,Simon C. Watkins,Gregory J. Naus,Daniel V. Landers,Bruce K. Patterson +6 more
TL;DR: It is demonstrated that memory CD4+ T cells and not Langerhans cells were the first HIV-1 RNA-positive cells detected at the epithelial-submucosal junction 6 h after virus exposure, indicating the utility of the organ culture to screen topical microbicides for their ability to block sexual transmission of HIV- 1.
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Biophysical insight into mechanisms of sonoporation
TL;DR: This work presents mechanistic, biophysical insight into sonoporation as a tool for local delivery of therapeutic macromolecules and shows that there exists a microbubble oscillation-induced shear-stress threshold, on the order of kilopascals, beyond which endothelial cellular membrane permeability increases.
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4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.
Ashley V. Menk,Nicole E. Scharping,Dayana Rivadeneira,Michael J. Calderon,McLane Watson,Deanna Dunstane,Simon C. Watkins,Greg M. Delgoffe +7 more
TL;DR: These studies highlight metabolic reprogramming as the dominant effect of 4-1BB therapy and suggest that combinatorial strategies using 4- 1BB agonism may help overcome the immunosuppressive metabolic landscape of the tumor microenvironment.
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STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Takayuki Ohkuri,Arundhati Ghosh,Akemi Kosaka,Jianzhong Zhu,Maki Ikeura,Michael David,Simon C. Watkins,Saumendra N. Sarkar,Hideho Okada +8 more
TL;DR: Significant contributions of STING to antitumor immunity via enhancement of type I IFN signaling in the tumor microenvironment are demonstrated and a potential use of STing agonists for the development of effective immunotherapy, such as the combination with antigen-specific vaccinations is suggested.