Simon C. Watkins

TL;DR: It is shown that autophagy occurs after both experimental and clinical TBI, and that oxidative stress contributes to overall neuropathology after TBI in mice, at least in part by initiating or influencing autophagosomes.

TL;DR: The results demonstrate the importance of topographic cues in instructing organization of the transparent connective tissue of the corneal stroma by differentiated keratocytes and will help with design of biomaterials for a bottom-up strategy to bioengineer spatially complex, collagen-based nano-structured constructs for cornesal repair and regeneration.

TL;DR: A predominant role for the caspase-8/Bid pathway is identified in signaling associated with hyperoxic lung injury and cell death in vivo and in vitro and, for the first time, it is identified that the response to hyperoxia in vivo predominantly involved the activation of the Bid/casp enzyme pathway without apparent increases in Bax expression.

TL;DR: Blockade of IL-33/ST2 interactions during allogeneic-hematopoietic cell transplantation by exogenous ST2-Fc infusions had a marked reduction in GVHD lethality, indicating a role of ST2 as a decoy receptor modulating GV HD.

TL;DR: It is proposed that the enhancement of muscle growth and regeneration, as well as the prevention of fibrotic development, could be used as approach(es) to improve the healing of muscle injuries.