S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal Article
Glioma-associated hyaluronan induces apoptosis in dendritic cells via inducible nitric oxide synthase: implications for the use of dendritic cells for therapy of gliomas.
Tianbing Yang,Timothy F. Witham,Lorissa Villa,Melanie Erff,Jason Attanucci,Simon C. Watkins,Douglas Kondziolka,Hideho Okada,Ian F. Pollack,William H. Chambers +9 more
TL;DR: Data indicate that HA expressed by gliomas may contribute to their immunosuppressive effects by promoting apoptosis among professional antigen-presenting cells such as DCs via iNOS induction after CD44-HA interactions.
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Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process.
Muwen Kong,Lili Liu,Xuejing Chen,Katherine I. Driscoll,Peng Mao,Stefanie Böhm,Neil M. Kad,Simon C. Watkins,Kara A. Bernstein,John J. Wyrick,Jung Hyun Min,Bennett Van Houten +11 more
TL;DR: Find that deletion of seven residues in the tip of β-hairpin in BHD3 increases Rad4-Rad23 constrained motion at the expense of stable binding at sites of DNA lesions, without diminishing cellular UV resistance or photoproduct repair in vivo.
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Viral gene delivery to skeletal muscle: insights on maturation-dependent loss of fiber infectivity for adenovirus and herpes simplex type 1 viral vectors.
W. G. Feero,J. D. Rosenblatt,Johnny Huard,Simon C. Watkins,Michael W. Epperly,Paula R. Clemens,Stefan Kochanek,Joseph C. Glorioso,Terence A. Partridge,Eric P. Hoffman +9 more
TL;DR: The hypothesis that the basal lamina acts as a physical barrier to HSV-1 infection of mature muscle, and, thus, is not solely due to host immune response, is supported.
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Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity.
Eric E. Kelley,Jeffrey J. Baust,Gustavo Bonacci,Franca Golin-Bisello,Jason Devlin,Claudette M. St. Croix,Simon C. Watkins,Sonia Gor,Nadiezhda Cantu-Medellin,Eric R. Weidert,Jefferson C. Frisbee,Mark T. Gladwin,Hunter C. Champion,Bruce A. Freeman,Nicholas K.H. Khoo +14 more
TL;DR: Observations support that the pleiotropic signalling actions of electrophilic fatty acids represent a therapeutic strategy for limiting the complex pathogenic responses instigated by obesity.
Journal ArticleDOI
Fixed-wing MAV attitude stability in atmospheric turbulence—Part 2: Investigating biologically-inspired sensors
Abdulghani Mohamed,Simon C. Watkins,Reece A. Clothier,Mujahid Abdulrahim,Kevin Massey,Roberto Sabatini +5 more
TL;DR: In this paper, a number of biological mechanoreceptors used by flying animals are explored for their utility in micro-air vehicles (MAVs) to sense the disturbances before a perturbation is induced.