Simon C. Watkins

TL;DR: Phenotypic analysis of cultured DCs from BM-augmented patients, unlike that of controls, exhibited a marked down-regulation of B7-1 (CD80) while retaining normal levels of expression of B 7-2 (CD86) cell surface molecules, suggesting that the chimerism in BM-AUgmented Patients is multilineage.

TL;DR: In this paper, the flowfield of externally mounted car mirrors is discussed and a wind-tunnel study of the local flowfield is presented, where mean velocities, pitch and yaw angles and turbulence intensities and spectra were measured using hot-wire anemometers.

TL;DR: The current demonstration of the interplay between inflammation and the induction of immunosuppressive factors by catecholamines suggest a contextual impact of stress, helping to explain variable results of epidemiologic studies of the link between sympathetic activity and cancer progression, and implicating COX-2 blockade as a potential means to mitigate stress-related immune suppression.

TL;DR: In the fibrotic liver, gliotoxin nonspecifically causes death of hepatic cell types and modification of gliot toxin molecule may be necessary for selective targeting and elimination of activated stellate cells.

TL;DR: CD40 signaling of DCs results in the highly efficient expression and presentation of transgenic antigens and the induction of "in vivo" cytotoxic T-cell responses specific for transgenic antigen peptides, demonstrating the functional potential of genetically engineered DCs.