S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.
Song My Hoang,Nicole Kaminski,Ragini Bhargava,Jonathan Barroso-González,Michelle L. Lynskey,Laura García-Expósito,Justin L. Roncaioli,Anne R. Wondisford,Callen T. Wallace,Simon C. Watkins,Dominic I. James,Ian D. Waddell,Donald J. Ogilvie,Kate M. Smith,Felipe da Veiga Leprevost,Dattatreya Mellacharevu,Alexey I. Nesvizhskii,Jianfeng Li,Dominique Ray-Gallet,Robert W. Sobol,Geneviève Almouzni,Roderick J. O’Sullivan +21 more
TL;DR: It is proposed that PARylation enables HIRA to fulfill its essential role in the adaptive response to ATRX deficiency that pervades ALT cancers.
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Enhancement of adult muscle regeneration by primary myoblast transplantation.
John F. Derosimo,Charles H. Washabaugh,Martin P. Ontell,Monica J. Daood,Jon F. Watchko,Simon C. Watkins,Bill T. Ameredes,Marcia Ontell +7 more
TL;DR: A possible role for the addition of exogenous, primary myoblasts in the treatment of traumatized and/or diseased muscles that are characterized by myofiber loss is suggested.
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Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells
Yimin Zhu,Donna B. Stolz,Fengli Guo,Mark A. Ross,Simon C. Watkins,Bee Jen Tan,Robert Z. Qi,E. D. Manser,Qiu-Tian Li,Boon-Huat Bay,Tian Seng Teo,Wei Duan +11 more
TL;DR: Results indicate that RhoA signals via the integral membrane pool of its effectors in its immediate vicinity at the plasma membrane, thus establishing a new paradigm in mammalian cell signaling.
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CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL
Gabor Csanyi,Gabor Csanyi,Douglas M. Feck,Pushpankur Ghoshal,Bhupesh Singla,Huiping Lin,Shanmugam Nagarajan,Daniel N. Meijles,Imad Al Ghouleh,Nadiezhda Cantu-Medellin,Eric E. Kelley,Lukasz Mateuszuk,Jeffrey S. Isenberg,Simon C. Watkins,Patrick J. Pagano +14 more
TL;DR: A new paradigm in which delimited Nox1-mediated redox signaling, independent of classical lipid oxidation, contributes to early propagation of vascular inflammatory disease is revealed.
Journal ArticleDOI
A zebrafish model of infection-associated acute kidney injury.
Xiaoyan Wen,Liyan Cui,Seth Morrisroe,Donald Maberry,David R. Emlet,Simon C. Watkins,Neil A. Hukriede,John A. Kellum +7 more
TL;DR: A zebrafish model of S-AKI induced by E. tarda injection is established, with both larval and adult zebra fish showing nephron injury in the setting of infection.