S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
Papers
More filters
Journal Article
Role of intestinal mucus in transepithelial passage of bacteria across the intact ileum in vitro.
Craig T. Albanese,Mario A. Cardona,Samuel D. Smith,Simon C. Watkins,Arlet G. Kurkchubasche,Ibrahim Ulman,Richard L. Simmons,Marc I. Rowe +7 more
TL;DR: Intestinal mucus secretion is a critical factor in the barrier function of the gut, and its depletion results in a dramatic increase in bacterial passage across the intact rat ileum.
Journal ArticleDOI
Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility.
TL;DR: It is reported that during EGF-induced motility, the leading edge's submembranous region constitutes a distinct subcellular locale that drives cytoskeletal rearrangement and protrusion.
Journal ArticleDOI
Induction of therapeutic antitumor immunity by in vivo administration of a lentiviral vaccine.
TL;DR: Observations indicate that direct in vivo administration of a lentiviral vaccine not only enhances antigen-specific CD8+ T cell responses, but also generates significant therapeutic antitumor activities.
Journal ArticleDOI
TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres
Jiangguo Lin,Preston Countryman,Noah Buncher,Parminder Kaur,Longjiang E,Yiyun Zhang,Greg Gibson,Changjiang You,Simon C. Watkins,Jacob Piehler,Patricia L. Opresko,Neil M. Kad,Hong Wang +12 more
TL;DR: It is proposed that the TRF proteins use 1D sliding to find protein partners and assemble the shelterin complex, which in turn stabilizes the interaction with specific telomeric DNA.
Journal ArticleDOI
Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes.
Patricia Loughran,Donna B. Stolz,Yoram Vodovotz,Simon C. Watkins,Richard L. Simmons,Timothy R. Billiar +5 more
TL;DR: iNOS exists in a least two pools in hepatocytes: a soluble pool composed of both active dimer and monomer and a peroxisomal pool of monomeric iNOS.