S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses.
Alicia R. Mathers,Brian M. Janelsins,Joseph P Rubin,Olga A. Tkacheva,William J. Shufesky,Simon C. Watkins,Adrian E. Morelli,Adriana T. Larregina +7 more
TL;DR: The data demonstrate that human epidermal smiLCs induce Th17 responses by mechanisms different from those previously described and highlight the need to target clinical treatments based on these variations.
Journal ArticleDOI
Inhibition of Nitric Oxide With Aminoguanidine Reduces Bacterial Translocation After Endotoxin Challenge In Vivo
Donald. L. Sorrells,Chris Friend,Ugur Koltuksuz,Anita P. Courcoulas,Patricia Boyle,Melissa Garrett,Simon C. Watkins,Marc I. Rowe,Henri R. Ford +8 more
TL;DR: Inhibition of nitric oxide production with AG decreases BT after high-dose LPS challenge, and the mechanism may involve increased cellular viability and decreased damage to the gut mucosal barrier in rats that receive AG.
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Pulmonary alveolar epithelial inducible NO synthase gene expression: regulation by inflammatory mediators.
Hector H. Gutierrez,Bruce R. Pitt,M. Schwarz,Simon C. Watkins,Charles J. Lowenstein,Isabella Caniggia,Phillip Chumley,B. A. Freeman +7 more
TL;DR: NO production by alveolar epithelium, which exceeds that of other lung cell types, reveals new insight into mechanisms of pulmonary host defense and pathways of free radical-mediated lung injury.
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Effective immunotherapy against murine gliomas using type 1 polarizing dendritic cells--significant roles of CXCL10.
Mitsugu Fujita,Xinmei Zhu,Ryo Ueda,Kotaro Sasaki,Gary Kohanbash,Edward R. Kastenhuber,Heather A. McDonald,Gregory A. Gibson,Simon C. Watkins,Ravikumar Muthuswamy,Pawel Kalinski,Hideho Okada +11 more
TL;DR: Findings show the anti-CNS glioma effects of DC1-based therapy and a novel role of CXCL10 in the immunologic and therapeutic activity of DC-based cancer vaccines.
Journal ArticleDOI
Flow structures in the near-wake of the Ahmed model
TL;DR: The time-averaged and time-dependent nature of the Ahmed model near-and far-wake has been investigated experimentally as mentioned in this paper, with the use of a new multi-hole probe allowing for measurement in regions exhibiting large flow angles (including flow reversals), and high levels of unsteadiness.