Simon C. Watkins

TL;DR: Progression of disc aging is examined in a murine model of a human progeroid syndrome caused by deficiency of the DNA repair endonuclease, ERCC1–XPF (Ercc1−/Δ mice) and novel evidence that DNA damage negatively impacts PG synthesis is provided.

TL;DR: It is confirmed that cultured sheep pulmonary artery endothelial cells (SPAECs) became resistant to lipopolysaccharide (LPS)-induced apoptosis several days after constitutive synthesis of nitric oxide (NO) after adenoviral transfer of inducible NO synthase (iNOS) or exposure to the NO donor S-nitroso- N-acetylpenicillamine (SNAP) and used all three approaches to determine underlying mechanisms of this phenomenon.

TL;DR: There is a need to refine the end-point of risk assessment studies that currently do not distinguish risk levels among unruptured aneurysms, and it is proposed that a measure of wall integrity that identifies this vulnerable wall subpopulation will be useful for interpreting future biological and structural data.

TL;DR: By cloning the cDNA encoding murine P84, it is discovered that this molecule is a member of a family of phosphatase-binding proteins and is identical to the murine SHPS-1 cDNA.

TL;DR: In vivo studies in intact hepatocytes provide novel findings not previously disclosed by in vitro studies, and indicates the importance of several mechanisms in contributing Bid-mediated mitochondria dysfunction that could be potential cellular targets of intervention.