Simon C. Watkins

TL;DR: The data support a model in which signals in the tumor microenvironment repress T cell oxidative metabolism, resulting in effector cells with metabolic needs that cannot be met and suggest that modulation or reprogramming of the altered metabolism of tumor-infiltrating T-cells might represent a potential strategy to reinvigorate dysfunctional T cells for cancer treatment.

TL;DR: It is concluded that basal cells represent an alternative multipotent progenitor cell population of bronchial airways and that progenitors cell selection is dictated by the type of airway injury.

TL;DR: Edited by Louis J. Ignarro, University of California, Los Angeles School of Medicine, Angeles, CA, and approved August 27, 2001.

TL;DR: Based on single-fiber analysis, skeletal muscle in obese and type 2 diabetic subjects mani-fests disturbances of oxidative enzyme activity and increased lipid content that are independent of the effect of fiber type are found.

TL;DR: Lipid accumulation within muscle fibers is significantly increased in obesity and is reduced by weight loss, which provides important information regarding the accumulation and distribution of skeletal muscle triglyceride in type 2 DM and obesity.