S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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The subcellular distribution of chromosome 6-encoded dystrophin-related protein in the brain.
TL;DR: The distribution of DRP is conserved across a large evolutionary distance, from mammals to elasmobranchs, suggesting that DRP may play a role in the maintenance of regional specializations in the brain.
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Growth and Muscle Defects in Mice Lacking Adult Myosin Heavy Chain Genes
Leslie Acakpo-Satchivi,Winfried Edelmann,Carol A. Sartorius,Brian D. Lu,Philip A. Wahr,Simon C. Watkins,Joseph M. Metzger,Leslie A. Leinwand,Raju Kucherlapati +8 more
TL;DR: Many of the phenotypes demonstrated by these mice are typical in human muscle disease and should provide insight into their etiology.
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A complex between Atg7 and caspase-9: a novel mechanism of cross-regulation between autophagy and apoptosis
TL;DR: It is proposed that the Atg7·caspase-9 complex performs a dual function of linking casp enzyme-9 to the autophagic process while keeping in check its apoptotic activity.
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Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury.
Brian G. Harbrecht,Bin Wu,Simon C. Watkins,Harry P. Marshall,Andrew B. Peitzman,Timothy R. Billiar +5 more
TL;DR: It is concluded that NO synthesis serves a protective function in preventing shock-induced hepatic injury and it is postulated that this effect may be due to modulation of the local hepatic circulation.
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AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells.
Michael M. Myerburg,J Darwin King,Nicholas M. Oyster,Adam Fitch,Amy Magill,Catherine J. Baty,Simon C. Watkins,Jay K. Kolls,Joseph M. Pilewski,Kenneth R. Hallows +9 more
TL;DR: The findings suggest that novel therapies to activate AMPK in the CF airway may be beneficial by blunting excessive sodium and ASL absorption and by reducing excessive airway inflammation, which are major contributors to CF lung disease.