S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide.
Hiromune Shimamura,Rachel Cumberland,Kazumasa Hiroishi,Simon C. Watkins,Michael T. Lotze,Joseph Baar +5 more
TL;DR: The authors report that ex vivo-generated murine DC induce the apoptosis of a panel of syngeneic and allogeneic murine tumors and demonstrate a novel mechanism for DC-induced tumor-cell apoptosis that does not require DC–tumor cell contact and is partially mediated by nitric oxide.
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Dynamic Sensitivity to Atmospheric Turbulence of Unmanned Air Vehicles with Varying Configuration
TL;DR: In this paper, the authors consider untethered flight tests of a small unmanned air vehicle in a large wind engineering tunnel that can be configured to replicate turbulence levels expected from urban and suburban environments.
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LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
Cliff Guy,Diana M. Mitrea,Po Chien Chou,Jamshid Temirov,Kate M. Vignali,Xueyan Liu,Hui Zhang,Richard W. Kriwacki,Marcel P. Bruchez,Simon C. Watkins,Creg J. Workman,Dario A. A. Vignali +11 more
TL;DR: In this paper , a phylogenetically conserved, acidic, tandem glutamic acid-proline repeat in the LAG3 cytoplasmic tail lowered the pH at the immune synapse and caused dissociation of the tyrosine kinase Lck from the CD4 or CD8 co-receptor, which resulted in a loss of coreceptor-TCR signaling and limited T cell activation.
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Impact of the Sensory Neurons on Melanoma Growth In Vivo.
TL;DR: It is reported that despite DRG cells not directly up-regulating proliferation of melanoma cells in vitro, presence of DRG neurons allows tumors to grow significantly faster in vivo, which justifies further investigations of the sensory (afferent) nervous system in the context of tumorigenesis and the local protumorigenic immunoenvironment.
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Alpha-sarcoglycan is recycled from the plasma membrane in the absence of sarcoglycan complex assembly.
TL;DR: It is demonstrated that the most commonly reoccurring limb girdle muscular dystrophy (R77C) mutation causes a fundamental defect in protein biosynthesis, trapping the mutant protein in the endoplasmic recticulum (ER).