S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Journal ArticleDOI
Correlation of the Tight Junction-like Distribution of Claudin-1 to the Cellular Tropism of Hepatitis C Virus
Wei Yang,Chao Qiu,Nabanita Biswas,Jing Jin,Simon C. Watkins,Ronald C. Montelaro,Carolyn B. Coyne,Tianyi Wang +7 more
TL;DR: The results suggest that the specific localization pattern of CLDN1 may be crucial in the regulation of HCV cellular tropism.
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Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes
Suzanne Bertera,Megan L. Crawford,Andrew L. Alexander,Glenn D. Papworth,Simon C. Watkins,Paul D. Robbins,Massimo Trucco +6 more
TL;DR: A significant prolongation of graft function suggests that the antioxidant activity of MnSOD is beneficial to transplanted islet survival and may be used in combination with other strategies aimed at islet graft protection.
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Tumor's other immune targets: dendritic cells.
Clemens Esche,Anna Lokshin,Galina V. Shurin,Brian R. Gastman,Hannah Rabinowich,Simon C. Watkins,Michael T. Lotze,Michael R. Shurin +7 more
TL;DR: It is demonstrated that tumors induce apoptosis in dendritic cells (DC) and a new mechanism of tumor escape from immune recognition is suggested and this finding will lead to improvement of DC‐based immunotherapies for cancer and other immune diseases.
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Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
Christian Hierholzer,Jörg C. Kalff,Laurel Omert,Katsuhiko Tsukada,J. Eric Loeffert,Simon C. Watkins,Timothy R. Billiar,David J. Tweardy +7 more
TL;DR: Findings indicate that IL-6 production and Stat3 activation occur early in HS and may contribute to PMN-mediated lung injury, including ARDS after HS.
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Overexpression of tumor necrosis factor- alpha activates both anti- and pro-apoptotic pathways in the myocardium.
Toru Kubota,Masayuki Miyagishima,Carole S. Frye,Sean Alber,George S. Bounoutas,Toshiaki Kadokami,Simon C. Watkins,Charles F. McTiernan,Arthur M. Feldman +8 more
TL;DR: The results suggest that TNF- α by itself is not sufficient to induce apoptosis in cardiac myocytes in vivo, and signaling pathways responsible for T NF-α induced apoptosis should be elucidated.