S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
Papers
More filters
Journal ArticleDOI
DNA-based immunization by in vivo transfection of dendritic cells
TL;DR: It is shown that cutaneous genetic immunization with naked DNA results in potent, antigen–specific, cytotoxic T lymphocyte–mediated protective tumor immunity and the feasibility of genetically engineering dendritic cells in vivo.
Journal ArticleDOI
Microbubbles Targeted to Intercellular Adhesion Molecule-1 Bind to Activated Coronary Artery Endothelial Cells
Flordeliza S. Villanueva,Ron J. Jankowski,Sasha Klibanov,Maris L. Pina,Sean Alber,Simon C. Watkins,Gary H. Brandenburger,William R. Wagner +7 more
TL;DR: A gas-filled microbubble with anti-ICAM-1 antibody on its shell specifically binds to activated ECs overexpressing ICam-1.
Journal ArticleDOI
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Charleen T. Chu,Jing Ji,Ruben K. Dagda,Jianfei Jiang,Yulia Y. Tyurina,Alexandr A. Kapralov,Vladimir A. Tyurin,Naveena Yanamala,Indira H. Shrivastava,Dariush Mohammadyani,Kent Z.Q. Wang,Jianhui Zhu,Judith Klein-Seetharaman,Krishnakumar Balasubramanian,Andrew A. Amoscato,Grigory G. Borisenko,Zhentai Huang,Aaron M. Gusdon,Amin Cheikhi,Erin Steer,Ruth Wang,Catherine J. Baty,Simon C. Watkins,Ivet Bahar,Hülya Bayır,Valerian E. Kagan +25 more
TL;DR: Red redistribution of cardiolipin serves as an ‘eat-me’ signal for the elimination of damaged mitochondria from neuronal cells as well as the engulfment of mitochondria by the autophagic system.
Journal ArticleDOI
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
Lori A. Birder,Y. Nakamura,Y. Nakamura,Susanna Kiss,Michele L. Nealen,Stacey Barrick,Anthony Kanai,Edward Wang,Giovanni W. Ruiz,W.C. de Groat,Gerard Apodaca,Simon C. Watkins,Michael J. Caterina +12 more
TL;DR: Findings indicate that TRPV1 participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.
Journal ArticleDOI
Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs
Donald G. Phinney,Michelangelo Di Giuseppe,Joel Njah,Ernest Sala,Sruti Shiva,Claudette M. St. Croix,Donna B. Stolz,Simon C. Watkins,Y. Peter Di,George D. Leikauf,Jay K. Kolls,David W. H. Riches,Giuseppe DeIuliis,Naftali Kaminski,Siddaraju V. Boregowda,David H. McKenna,Luis A. Ortiz +16 more
TL;DR: It is shown that MSCs manage intracellular oxidative stress by targeting depolarized mitochondria to the plasma membrane via arrestin domain-containing protein 1-mediated microvesicles and simultaneously shed micro RNA-containing exosomes that inhibit macrophage activation by suppressing Toll-like receptor signalling.