S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
Papers
More filters
Journal Article
Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.
Lien Lu,Clark A. Bonham,F G Chambers,Simon C. Watkins,Rosemary A. Hoffman,Richard L. Simmons,Angus W. Thomson +6 more
TL;DR: Although DC function initially as the most potent APCs for T cell activation, DC induced to synthesize NOS by IFN-gamma may inhibit (allogeneic) T cell proliferation: NO may suppress lymphocyte proliferation and also induce apoptosis of the most powerful source of alloantigenic stimulation.
Journal ArticleDOI
Regulation of Sar1 NH2 terminus by GTP binding and hydrolysis promotes membrane deformation to control COPII vesicle fission
TL;DR: Sar1-mediated GTP binding and hydrolysis regulates the NH2-terminal tail to perturb membrane packing, promote membrane deformation, and control vesicle fission.
Journal ArticleDOI
Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors
Song Li,Su Ping Wu,Mark Whitmore,Eric Loeffert,Lin Wang,Simon C. Watkins,Bruce R. Pitt,Leaf Huang +7 more
TL;DR: It is reported that cationic lipid-protamine-DNA complexes, but not each component alone, can induce a high level of cytokine production, including interferon-γ and tumor necrosis factor-α, and it is demonstrated that LPD administration triggers apoptosis in the lung, a phenomenon that may be mediated in part by the two cytokines.
Journal ArticleDOI
Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death.
Dirk-Jan Slebos,Stefan W. Ryter,Marco van der Toorn,Fang Liu,Fengli Guo,Catherine J. Baty,Jenny M. Karlsson,Simon C. Watkins,Hong Pyo Kim,Xue Wang,Janet S. Lee,Dirkje S. Postma,Henk F. Kauffman,Augustine M.K. Choi +13 more
TL;DR: The functional compartmentalization of heme oxygenase-1 in the mitochondria of lung epithelial cells, and its potential role in defense against mitochondria-mediated cell death during CSE exposure are demonstrated.
Journal ArticleDOI
DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages.
Giovanna Rappocciolo,Frank J. Jenkins,Heather R. Hensler,Paolo Piazza,Mariel Jais,Luann Borowski,Simon C. Watkins,Charles R. Rinaldo +7 more
TL;DR: It is proposed that dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209) is a receptor for HHV-8 infection of myeloid DCs and macrophages and serves as a portal for immune dysfunction and oncogenesis caused by HHV -8 infection.