Simon C. Watkins

TL;DR: This work generates a cell system to selectively manipulate the nucleo-cytoplasmic levels of acetyl-CoA using CRISPR-mediated gene editing and acetate supplementation of the culture media and demonstrates that acetyl -CoA depletion alters the integrity of the nucleolus, impairing Ribosomal RNA synthesis and evoking the ribosomal protein-dependent activation of p53.

TL;DR: A microfluidic device that concurrently generates three different levels of uniform wall shear stress (W SS) and six different WSS gradients (WSSG) is developed and can be used to dissect the mechanisms underlying EC responses to different W SS modalities, including shear Stress gradients, and to investigate the influence of flow on a diverse range of cells during development, homeostasis and disease.

TL;DR: A new organelle found in a case of Duchenne muscular dystrophy was located at the periphery of a regenerated myofibre close to a satellite cell and consisted of parallel arrays of laminae or, possibly, filaments.