S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
Peng Shang,Nadezda A. Stepicheva,Kenneth Teel,Austin McCauley,Christopher Scott Fitting,Stacey Hose,Rhonda Grebe,Meysam Yazdankhah,Sayan Ghosh,Haitao Liu,Anastasia Strizhakova,Joseph Weiss,Imran Ahmed Bhutto,Gerard A. Lutty,Ashwath Jayagopal,Jiang Qian,José-Alain Sahel,José-Alain Sahel,J. Samuel Zigler,James T. Handa,Yuri V. Sergeev,Raju V. S. Rajala,Simon C. Watkins,Debasish Sinha,Debasish Sinha +24 more
TL;DR: In this article, the authors demonstrate an important role for βA3/A1-crystallin in RPE, and show that βA 3/A 1-crystalin deficiency leads to clathrin-mediated epidermal growth factor receptor (EGFR) endocytosis abnormalities and actin network disruption at the apical side that result in rPE polarity disruption and degeneration.
Effects of venting geometry on thermal comfort and aerodynamic efficiency of bicycle helmets
TL;DR: The Impact of Technology on sport II as discussed by the authors provides a deeper insight into the current status of sports technology and to present recent developments in this area from the perspective of different disciplines, industrial practice, academia and athletes.
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Transendothelial Perforations and the Sphere of Influence of Single-Site Sonoporation.
TL;DR: The biophysical context of endothelial sonoporation repair with application in drug/gene delivery is established and the critical role of membrane line tension in perforation resealing velocity is established.
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Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis.
Zheqi Li,Yangjiazi Wu,Megan E. Yates,Nilgun Tasdemir,Amir Bahreini,Jian Chen,Kevin M. Levine,Nolan Priedigkeit,Azadeh Nasrazadani,Simak Ali,Laki Buluwela,Spencer Arnesen,Jay Gertz,Jennifer K. Richer,Benjamin Troness,Dorraya El-Ashry,Qiang Zhang,Lorenzo Gerratana,Youbin Zhang,Massimo Cristofanilli,M.A. Montañez,Prithu Sundd,Callen T. Wallace,Simon C. Watkins,Caterina Fumagalli,Elena Guerini-Rocco,Lin Zhu,George C. Tseng,Nikhil Wagle,Jason S. Carroll,Paul Jank,Carsten Denkert,Maria Karsten,Jens-Uwe Blohmer,Ben Ho Park,Peter C. Lucas,Jennifer M. Atkinson,Adrian T. Lee,Steffi Oesterreich +38 more
TL;DR: Mechanistically, mutant ESR1 exhibited non-canonical regulation of several metastatic pathways, including secondary transcriptional regulation and de novo FOXA1-driven chromatin remodeling, which provides evidence for ESR 1 mutation-modulated metastasis and suggest future therapeutic strategies for targeting E SR1 mutant breast cancer.
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Tim-3 mediates T cell trogocytosis to limit antitumor immunity
Ornella Pagliano,Robert E. Morrison,Joe-Marc Chauvin,Hridesh Banerjee,Diwakar Davar,Quanquan Ding,Tokiyoshi Tanegashima,Wentao Gao,S. Chakka,Richelle DeBlasio,Ava Lowin,k-I Kara,Mignane B. Ka,Bochra Zidi,Rada Amin,Itay Raphael,Shuowen Zhang,Simon C. Watkins,Cindy Sander,John M. Kirkwood,Marcus Bosenberg,J. Anderson,Vijay K. Kuchroo,Lawrence P. Kane,Alan J. Korman,Arvind Rajpal,Sean M. West,Min Guk Han,Christine Bee,Xiaodi Deng,Xiao Min Schebye,Pavel Strop,Hassane M. Zarour +32 more
TL;DR: It is shown that human programmed cell death 1–positive (PD-1+) Tim-3+CD8+ tumor-infiltrating lymphocytes (TILs) upregulate phosphatidylserine (PS) and acquire cell surface myeloid markers from antigen-presenting cells (APCs) through transfer of membrane fragments called trogocytosis.