S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
Papers
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Journal ArticleDOI
Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy.
Yun You Li,Y. Q. Feng,T. Kadokami,C. F. McTiernan,R. Draviam,Simon C. Watkins,Arthur M. Feldman +6 more
TL;DR: The results suggest a critical role of TNF-alpha and MMPs in myocardial matrix remodeling and functional regulation and support the hypothesis that both TNFs and M MPs may serve as potential therapeutic targets in the treatment of heart failure.
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Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production
Adrian E. Morelli,Adriana T. Larregina,William J. Shufesky,Alan F. Zahorchak,Alison J. Logar,Glenn D. Papworth,Zhiliang Wang,Simon C. Watkins,Louis D. Falo,Angus W. Thomson +9 more
TL;DR: Characterization of apoptotic cell/DC interaction and its outcome provides insight into the mechanisms by which apoptotic cells affect DC function without disrupting peripheral tolerance.
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The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
TL;DR: It is reported that insulin stimulation of HIRcB fibroblasts leads to accumulation of Ras, Raf-1, phosphorylated MEK,osphorylated MAPK, and PA on endosomal membranes and results indicate that agonist-dependent Raf- 1 translocation is primarily mediated by a direct interaction with PA and is independent of association with Ras.
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Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor
Sanjay K. Mishra,Peter A. Keyel,Matthew J. Hawryluk,Nicole R. Agostinelli,Simon C. Watkins,Linton M. Traub +5 more
TL;DR: It is proposed that Dab2 is a typical member of a growing family of cargo‐specific adaptor proteins, including β‐arrestin, AP180, epsin, HIP1 and numb, which regulate clathrin‐coat assembly at the plasma membrane by synchronizing cargo selection and lattice polymerization events.
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Somatic reversion/suppression of the mouse mdx phenotype in vivo.
TL;DR: The mdx mouse has a myopathy caused by dystrophin deficiency, and is therefore biochemically and genetically homologous to human Duchenne muscular dystrophy and a possible estimate of the somatic reversion rate of the mdx mutation in vivo is considered.