S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
Papers
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Journal ArticleDOI
Mycoplasma fermentans and TNF-β interact to amplify immune-modulating cytokines in human lung fibroblasts
James P. Fabisiak,Fei Gao,Robyn G. Thomson,Robert M. Strieter,Simon C. Watkins,James H. Dauber +5 more
TL;DR: M. fermentans interacts with stimuli such as TNF-beta to amplify lung cell production of immune-modulating cytokines and is uniquely sensitive to delayed application of SP-600125, suggesting that JNK/stress-activated protein kinase contributes to the amplification of IL-6 release.
Proceedings ArticleDOI
On the causes of image blurring in external rear view mirrors
TL;DR: In this article, the authors reviewed possible causes of the mirror vibration, including road inputs from the vehicle body and a variety of aerodynamic inputs, including the A-pillar vortex, the turbulent flow field, and the base pressure fluctuations.
Journal ArticleDOI
Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors.
Laura Molina,Junjie Zhu,Qin Li,Tirthadipa Pradhan-Sundd,Yekaterina Krutsenko,Khaled Sayed,Nathaniel E. C. Jenkins,Ravi Vats,Bharat Bhushan,Sungjin Ko,Shikai Hu,Minakshi Poddar,Sucha Singh,Junyan Tao,Prithu Sundd,Aatur D. Singhi,Simon C. Watkins,Xiaochao Ma,Panayiotis V. Benos,Andrew Feranchak,George K. Michalopoulos,Kari Nejak-Bowen,Alan M. Watson,Aaron Bell,Satdarshan P.S. Monga +24 more
TL;DR: In this article, the authors detect YAP1 activity in biliary cells and in cells at the hepatobiliary bifurcation in single-cell RNA sequencing analysis of developing livers.
Book ChapterDOI
Migration of Cultured Chimpanzee Dendritic Cells Following Intravenous and Subcutaneous Injection
TL;DR: It is now possible to grow large numbers of dendritic cells from a patient’s blood or bone marrow in vitro, treat these cells with tumor-associated antigens, and administer to the donor with the aim of inducing a strong and therapeutic immune response to the tumor.
Journal ArticleDOI
P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis
Haider H. Dar,Michael W. Epperly,Vladimir A. Tyurin,Andrew A. Amoscato,Tamil S. Anthonymuthu,Austin B. Souryavong,Alexandr A. Kapralov,Galina V. Shurin,S. N. Samovich,Claudette M. St. Croix,Simon C. Watkins,Sally E. Wenzel,Rama K. Mallampalli,Joel S. Greenberger,Hülya Bayır,Valerian E. Kagan,Yulia Y. Tyurina +16 more
TL;DR: Unearthing complex PAO1 pathogenic/virulence mechanisms, including effects on the host anti/proinflammatory responses, lipid metabolism, and ferroptotic cell death, points toward potentially new therapeutic and radiomitigative targets.