S
Simon C. Watkins
Researcher at University of Pittsburgh
Publications - 999
Citations - 75771
Simon C. Watkins is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Apoptosis & Immune system. The author has an hindex of 135, co-authored 950 publications receiving 68358 citations. Previous affiliations of Simon C. Watkins include Harvard University & Children's National Medical Center.
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Delivery of a cyclic adenosine 3',5'-monophosphate response element-binding protein (creb) mutant to seminiferous tubules results in impaired spermatogenesis.
M Scobey,Suzanne Bertera,Jeremy P. Somers,Simon C. Watkins,Anthony J. Zeleznik,William H. Walker +5 more
TL;DR: Data demonstrate that AdCREBm1 causes apoptosis and elimination of germ cells and suggest that CREB is required to produce a Sertoli cell-derived factor that is critical for germ cell survival.
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Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
Christopher H. Choy,Golam T. Saffi,Matthew A. Gray,Callen T. Wallace,Roya M. Dayam,Zhen-Yi A. Ou,Guy M. Lenk,Rosa Puertollano,Simon C. Watkins,Roberto J. Botelho +9 more
TL;DR: PIKfyve inhibition causes lysosomes to coalesce, resulting in fewer, enlarged lYSosomes; TFEB-mediated lysOSome biosynthesis does not contribute to swelling.
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Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia
Melina R. Kibbe,Edith Tzeng,Susan L. Gleixner,Simon C. Watkins,Imre Kovesdi,Alena Lizonova,Michel S. Makaroun,Timothy R. Billiar,Robert Y. Rhee +8 more
TL;DR: Adenoviral inducible nitric oxide synthase (iNOS) gene transfer could inhibit intimal hyperplasia (IH) in porcine internal jugular veins interposed into the carotid artery circulation with potential for iNOS-based genetic modification of vein grafts to prolong graft patency.
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Gene expression profiling of target genes in ventilator-induced lung injury
Tamas Dolinay,Naftali Kaminski,Martina Felgendreher,Hong P. Kim,Paul R. Reynolds,Simon C. Watkins,Dörte Karp,Stefan Uhlig,Augustine M.K. Choi +8 more
TL;DR: In this article, gene expression profiling analysis of 20,000 mouse genes in isolated blood-free (to exclude genes from sequestered leukocytes) perfused mouse lungs exposed to low-pressure ventilation (10 cmH2O), high pressure ventilation (25 cmH 2O, overventilation), and LPS treatment was performed.
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Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.
Wentao Gao,Jeong Han Kang,Yong Liao,Wen-Xing Ding,Andrea Gambotto,Simon C. Watkins,Yong Jian Liu,Donna B. Stolz,Xiao Ming Yin +8 more
TL;DR: A novel approach to examine the LC3-positive compartment in cell-free lysates revealed that they were actually tubulovesicular structures with considerable heterogeneity, and suggested that double-membrane vesicles could be derived from single membrane compartments via different means, including tubule-to-vesicle conversion.