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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
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Journal ArticleDOI
Multiplexed Isobaric Tag‐Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy
TL;DR: The authors hypothesize that both tissue‐specific and global protein abundance alterations result from nicotine exposure, and present the first proteomic profiling of multiple tissues from mice treated orally with nicotine.
Patent
Capture and release based isotope tagged peptides and methods for using the same
TL;DR: In this article, the authors provide isotope tagged peptides, chemistries for making these peptides and methods for using these peptide, which can be used for rapid and quantitative analysis of proteins or protein function in mixtures of proteins.
Journal ArticleDOI
Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages
Derek R. Clements,JP Murphy,Andra M. Sterea,Barry E. Kennedy,Youra Kim,Erin Helson,Shekoufeh Almasi,Namit Holay,Prathyusha Konda,Joao A. Paulo,Tanveer Sharif,Patrick W. K. Lee,Michael P. Weekes,Steven P. Gygi,Shashi Gujar +14 more
TL;DR: The use of quantitative proteomics is elucidated to reveal the role and response of distinct immune cell populations throughout the course of virus infection and how these cells phenotypically, functionally, and metabolically undergo a timely transition from inflammatory to M2-like macrophages in vivo.
Journal ArticleDOI
A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel
Peiqiang Feng,Xudong Wu,Satchal K. Erramilli,Joao A. Paulo,Pawel Knejski,Steven P. Gygi,Anthony A. Kossiakoff,Tom A. Rapoport +7 more
TL;DR: In this paper , the N terminus of a recycling receptor is inserted from the peroxisomal lumen into the pore and monoubiquitylated by ring finger 2 (RF2) to enable extraction into the cytosol.
Journal ArticleDOI
Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
TL;DR: It is hypothesize that large scale proteomic alterations are prevalent upon the substitution of glucose with another carbon source, in this case pyruvate, and developed an updated streamlined-tandem mass tag (SL-TMT) strategy with more versatile bead-based protein aggregation.