S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Carboxyl-ester lipase Maturity-Onset Diabetes of the Young is Associated with Development of Pancreatic Cysts and Upregulated MAPK Signaling in Secretin-stimulated duodenal fluid
Helge Ræder,Fiona E. McAllister,Erling Tjora,Erling Tjora,Shweta Bhatt,Ingfrid S. Haldorsen,Ingfrid S. Haldorsen,Jiang Hu,Stefan M. Willems,Mette Vesterhus,Abdelfattah El Ouaamari,Manway Liu,Maria B. Ræder,Heike Immervoll,Heike Immervoll,Dag Hoem,Georg Dimcevski,Pål R. Njølstad,Pål R. Njølstad,Anders Molven,Anders Molven,Steven P. Gygi,Rohit N. Kulkarni +22 more
TL;DR: It is shown that subjects with CEL-MODY develop multiple pancreatic cysts by the time they develop diabetes and that upregulated MAPK signaling in the pancreatic secretome may reflect the pathophysiological development of pancreatic Cysts and diabetes.
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Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.
Hongying Shen,Shawn M. Ferguson,Noah Dephoure,Ryan J. Park,Yan Yang,Laura A. Volpicelli-Daley,Steven P. Gygi,Joseph Schlessinger,Pietro De Camilli +8 more
TL;DR: This finding reveals a link between the progression of clathrin-coated pits to endocytic vesicles and an activation-deactivation cycle of Ack, a tyrosine kinase.
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The effects of nonignorable missing data on label-free mass spectrometry proteomics experiments
Jonathon J. O’Brien,Harsha P. Gunawardena,Joao A. Paulo,Xian Chen,Joseph G. Ibrahim,Steven P. Gygi,Bahjat F. Qaqish +6 more
TL;DR: The analysis suggests that the proposed Bayesian selection model, compared with various imputation strategies and complete-case analyses, can increase accuracy and provide substantial improvements to interval coverage.
Journal ArticleDOI
An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis.
Jordan B. Jastrab,Tong Wang,J. Patrick Murphy,Lin Bai,Kuan Hu,Kuan Hu,Remco Merkx,Jessica Huang,Champak Chatterjee,Huib Ovaa,Steven P. Gygi,Huilin Li,Huilin Li,K. Heran Darwin +13 more
TL;DR: These studies show for the first time that an ATP-independent proteasomal-degradation pathway plays a role in the physiology of an important human pathogen and demonstrate that ATP- independent proteasome activators are not confined to eukaryotes and can contribute to the virulence of one the world's most devastating pathogens.
Journal ArticleDOI
eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference
Tingfang Yi,Haribabu Arthanari,Barak Akabayov,Barak Akabayov,Huai-Dong Song,Evangelos Papadopoulos,Hank H. Qi,Mark P. Jedrychowski,Thomas Güttler,Cuicui Guo,Rafael E. Luna,Steven P. Gygi,Stephen A. Huang,Gerhard Wagner +13 more
TL;DR: The results suggest that eIF1A is a novel component of the Ago2-centered RNA induced silencing complexes (RISCs) and augments Ago1-dependent RNAi and miRNA biogenesis and directly interacts with Ago2 and promotes Ago2 activities in RNA i and miR-451 biogenesis.