S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
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Journal ArticleDOI
Regulation of protein abundance in genetically diverse mouse populations
Gregory R. Keele,Tian Zhang,Duy Pham,Matthew Vincent,Timothy A. Bell,Pablo Hock,Ginger D. Shaw,Joao A. Paulo,Steven C. Munger,Fernando Pardo-Manuel de Villena,Martin T. Ferris,Steven P. Gygi,Gary A. Churchill +12 more
TL;DR: It is found that regulatory effects on individual proteins are conserved across the mouse populations, in particular for local genetic variation and sex differences, and proteins that form complexes are often co-regulated, displaying varying genetic architectures and overall show lower heritability and map fewer pQTLs.
Patent
Detection and quantification of modified proteins
Steven P. Gygi,Junmin Peng +1 more
TL;DR: In this paper, a method for detecting and quantifying proteins by mass spectrophotometric analysis using peptide internal standards and providing a highly sensitive way of detecting protein modifications was proposed.
Journal ArticleDOI
Improved Method for Determining Absolute Phosphorylation Stoichiometry Using Bayesian Statistics and Isobaric Labeling
TL;DR: The stoichiometry method is improved through the use of isobaric labeling with 10-plex TMT reagents and a Bayesian model to estimate phosphorylation stoichiometric as a parameter confined to an interval between 0 and 1 implemented as an R/Stan script is developed.
Journal ArticleDOI
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models.
Satoshi Muraoka,Mark P. Jedrychowski,Naotoshi Iwahara,Mohammad Abdullah,Kristen D. Onos,Kelly J. Keezer,Jianqiao Hu,Seiko Ikezu,Gareth R. Howell,Steven P. Gygi,Tsuneya Ikezu +10 more
TL;DR: In this paper, a high-resolution proteomic profiling of extracellular vesicles (EVs) separated from animal models of AD would determine the composition of EV contents and their cellular origin.
Journal ArticleDOI
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum
Elizabeth S. Egan,Elizabeth S. Egan,Elizabeth S. Egan,Michael P. Weekes,Michael P. Weekes,Usheer Kanjee,Jale Manzo,Ashwin Srinivasan,Christine Lomas-Francis,Connie M. Westhoff,Junko Takahashi,Mitsunobu Tanaka,Seishi Watanabe,Carlo Brugnara,Steven P. Gygi,Yoshihiko Tani,Manoj T. Duraisingh +16 more
TL;DR: It is demonstrated that host ATP binding cassette transporter ABCB6, which encodes the Langereis blood group antigen, promotes erythrocyte invasion by the malaria parasite Plasmodium falciparum, and suggests that asymptomatic LangereIS null individuals may be better protected from malaria.