S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Alternative RISC assembly: Binding and repression of microRNA–mRNA duplexes by human Ago proteins
Maja M. Janas,Maja M. Janas,Bingbing Wang,Bingbing Wang,Abigail S. Harris,Mike Aguiar,Jonathan M. Shaffer,Yerramilli V.B.K. Subrahmanyam,Mark A. Behlke,Kai W. Wucherpfennig,Steven P. Gygi,Etienne Gagnon,Carl D. Novina,Carl D. Novina +13 more
TL;DR: It is demonstrated that Agos can bind and repress miRNA-mRNA duplexes and support a model of catalytic Ago function in translational repression, implying the existence of miRNAs not stoichiometrically bound by Agos.
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pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise
Anita Reddy,Luiz H.M. Bozi,Luiz H.M. Bozi,Omar K. Yaghi,Evanna L. Mills,Haopeng Xiao,Hilary E. Nicholson,Margherita Paschini,Joao A. Paulo,Ryan Garrity,Dina Laznik-Bogoslavski,Julio C.B. Ferreira,Christian S. Carl,Kim A. Sjøberg,Jørgen F. P. Wojtaszewski,Jacob Jeppesen,Bente Kiens,Steven P. Gygi,Erik A. Richter,Diane Mathis,Edward T. Chouchani +20 more
TL;DR: A bioenergetic sensor in muscle is defined that utilizes intracellular pH and succinate to coordinate tissue adaptation to exercise.
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A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature Characterization
Brian K. Erickson,Christopher M. Rose,Craig R. Braun,Alison R. Erickson,Jeffrey Knott,Graeme C. McAlister,Martin Wühr,Joao A. Paulo,Robert A. Everley,Steven P. Gygi +9 more
TL;DR: A two-dimensional multiplexing workflow is presented that utilizes synthetic peptides for each protein to prompt the simultaneous quantification of >100 peptides from up to ten mixed sample conditions and elucidated a correlation between the expression of key proteins and their cellular response to drug treatment.
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A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability
Brenda C. O'Connell,Britt Adamson,Britt Adamson,Britt Adamson,John R. Lydeard,Mathew E. Sowa,Alberto Ciccia,Alberto Ciccia,Alberto Ciccia,Andrea L. Bredemeyer,Andrea L. Bredemeyer,Andrea L. Bredemeyer,Michael R. Schlabach,Michael R. Schlabach,Michael R. Schlabach,Steven P. Gygi,Stephen J. Elledge,Stephen J. Elledge,Stephen J. Elledge,J. Wade Harper +19 more
TL;DR: This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway and provides a resource for discovery of additional components of this pathway.
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The histone demethylase LSD1/KDM1A promotes the DNA damage response
Nima Mosammaparast,Haeyoung Kim,Benoit Laurent,Yu Zhao,Hui Jun Lim,Mona C. Majid,Sebastian Dango,Yuying Luo,Kristina Hempel,Mathew E. Sowa,Steven P. Gygi,Hanno Steen,J. Wade Harper,Bruce A. Yankner,Yang Shi +14 more
TL;DR: The E3 ubiquitin ligase RNF168 recruits LSD1 to DNA damage sites, where it reduces histone methylation upstream of 53BP1 recruitment during the DNA damage response.