Steven P. Gygi

TL;DR: Data show that endogenous IP3R1 is tagged with an array of ubiquitin conjugates at multiple sites and that both IP3 R1 ubiquitination and degradation are highly complex processes.

TL;DR: Simulation and experimental results show that the selection of a subset of heating temperatures ameliorates the small difference problem and improves the PISA assay.

TL;DR: A regulatory mechanism operating as a molecular switch is described, where in the absence of DNA damage, the FANCD2/FANCI complex is prevented from loading onto DNA, effectively suppressing the FA pathway.

TL;DR: In this article, the authors proposed a system for automatically performing liquid chromatography analysis of low volume liquid chemical samples at nanosecond flow rates using an analysis column that integrates a pre-concentration trapping column and a chromatography separation column terminating at an electrospray nozzle of an online mass spectrometer.

TL;DR: It is shown in vertebrate cells that Abl binds to CLASP and phosphorylates it in response to serum or PDGF stimulation, and the data suggest that the functional relationship between Abl and CLASp2 is conserved and provides a means to control theCLASP2 association with the cytoskeleton.