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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.
Melodie Knowlton,Laura M. Selfors,Carolyn N. Wrobel,Ting-Lei Gu,Bryan A. Ballif,Steven P. Gygi,Roberto D. Polakiewicz,Joan S. Brugge +7 more
TL;DR: In this article, the authors conducted quantitative mass spectrometry utilizing stable isotope labeling (SILAC) analysis to profile candidate SRC-substrates induced by the CSF-1R tyrosine kinase by comparing the phosphotyrosine-containing peptides from cells expressing either CSF1R or a mutant form of this RTK that is unable to bind to SRCs.
Journal ArticleDOI
Neutral Loss Is a Very Common Occurrence in Phosphotyrosine-Containing Peptides Labeled with Isobaric Tags
TL;DR: It is found pY peptide neutral loss behavior was consistent with reduced proton mobility, and does not occur during ETD, which has implications during instrument method development and interpretation of MS/MS spectra, and therefore ensuing follow-up studies.
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CDC7-independent G1/S transition revealed by targeted protein degradation
Jan M. Suski,Nalin Ratnayeke,Marcin Braun,Tian Zhang,Vladislav Strmiska,Wojciech Michowski,Geylani Can,Antoine Simoneau,Konrad Snioch,Mikołaj Cup,Caitlin Sullivan,Xiaoji Wu,Joanna Nowacka,Timothy Branigan,Lindsey R. Pack,James A. DeCaprio,Yan Geng,Lee Zou,Steven P. Gygi,Johannes C. Walter,Tobias Meyer,Piotr Sicinski +21 more
TL;DR: In this paper , it was shown that CDC7 is dispensable for cell division of many different cell types, as determined using chemical genetic systems that enable acute shutdown of CDC7 in cultured cells and in live mice.
Transcriptional role of cyclin D1 in development revealed by a “genetic-proteomic” screen
Frédéric Bienvenu,Siwanon Jirawatnotai,Siwanon Jirawatnotai,Joshua E. Elias,Joshua E. Elias,Clifford A. Meyer,Karolina Mizeracka,Alexander Marson,Garrett M. Frampton,Megan F. Cole,Duncan T. Odom,Junko Odajima,Yan Geng,Agnieszka Zagozdzon,Marie Jecrois,Richard A. Young,X. Shirley Liu,Constance L. Cepko,Steven P. Gygi,Piotr Sicinski +19 more
TL;DR: These studies show that in addition to its well-established cell cycle roles, cyclin’D1 has an in vivo transcriptional function in mouse development, which can be used to study the in vivo function of essentially any protein.
Journal ArticleDOI
Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity
Matthew L. Turnbull,Helen M. Wise,Marlynne Q. Nicol,Nikki Smith,Rebecca L. Dunfee,Philippa M. Beard,Brett W. Jagger,Yvonne Ligertwood,Gareth Hardisty,Haixia Xiao,D.J. Benton,Alice M. Coburn,Joao A. Paulo,Steven P. Gygi,John W. McCauley,Jeffery K. Taubenberger,Samantha Lycett,Michael P. Weekes,Bernadette M. Dutia,Paul Digard +19 more
TL;DR: The role of IAV segment 8 is investigated and it is concluded that B-allele segment 8 genes are, in fact, capable of supporting infection in mammals and that they should be considered during the assessment of the pandemic risk of zoonotic influenza A viruses.