S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells.
Dawn L. MacLellan,Hanno Steen,Rosalyn M. Adam,Monica Garlick,David Zurakowski,Steven P. Gygi,Michael R. Freeman,Keith R. Solomon +7 more
TL;DR: Observations suggest a role for lipid rafts in regulation of PDGF‐stimulated changes in the cytoskeleton, and specifically, eight Rho family members were localized to rafts by ICAT analysis.
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PP2ARts1 is a master regulator of pathways that control cell size
Jessica Zapata,Noah Dephoure,Tracy MacDonough,Yaxin Yu,Emily J. Parnell,Meghan Mooring,Steven P. Gygi,David J. Stillman,Douglas R. Kellogg +8 more
TL;DR: PP2ARts1 controls diverse pathways that influence cell size and may link cell cycle entry to cell growth via the transcription factor Ace2.
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Cdc28-Dependent Regulation of the Cdc5/Polo Kinase
TL;DR: It is shown that signaling from Cdc28 is required to maintain Cdc5 activity in vivo and for kinase activity in vitro, and results suggest that CDC28 activates CDC5 via phosphorylation of threonine 242.
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A solid phase extraction-based platform for rapid phosphoproteomic analysis.
Noah Dephoure,Steven P. Gygi +1 more
TL;DR: A modified two-step enrichment strategy that employs lysC digestion and step elution from self-packed strong cation exchange (SCX) solid phase extraction (SPE) columns followed by immobilized metal ion affinity chromatography (IMAC) and LC-MS/MS analysis using a hybrid LTQ Orbitrap Velos mass spectrometer is described.
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Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation
Ceri Alan Fielding,Michael P. Weekes,Luis Nobre,Eva Ruckova,Gavin S. Wilkie,Joao A. Paulo,Chiwen Chang,Nicolás M. Suárez,James A. Davies,Robin Antrobus,Richard J. Stanton,Rebecca Aicheler,Hester Nichols,Borek Vojtesek,John Trowsdale,Andrew J. Davison,Steven P. Gygi,Peter Tomasec,Paul J. Lehner,Gavin W. G. Wilkinson +19 more
TL;DR: It is demonstrated that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors and is identified as a major new hub of immune regulation.