Steven P. Gygi

TL;DR: An approach for rapid isolation of early/sorting endosomes through affinity capture of the early endosome-associated protein EEA1 (Endo-IP) is developed and proteomic and lipidomic snapshots of earlyendosomes in action are provided, revealing that products of Aβ processing by β- and γ-Secretases, and alterations in the specificity of cleavage by small molecule γ

TL;DR: In this article , the effects of partial chemical reprogramming on the epigenome, transcriptome, proteome, phosphoproteome, and metabolome of mouse fibroblasts were investigated.

TL;DR: This study provides a foundation for understanding systemic aging at the protein level by performing discovery-based proteomics in 10 tissues from C57BL/6J mice, representing both sexes at adult and late midlife ages.

TL;DR: In this article, the authors present methods of identifying phosphorylation sites in peptides and motifs of motifs for identifying sites of interest in peptide compositions and anti-phosphopeptide antibody compositions.

TL;DR: This manuscript was submitted in error therefore, the authors do not wish this work to be cited as reference for the project.