S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
More filters
Journal ArticleDOI
S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains
TL;DR: S5a (and presumably certain other UIM proteins) function with certain E3/E2 pairs to ensure synthesis of efficiently degraded non‐forked Ub conjugates and to prevent proteasomal degradation.
Journal ArticleDOI
Evaluation of the utility of neutral-loss-dependent MS3 strategies in large-scale phosphorylation analysis.
TL;DR: It is concluded that the collection of MS3 or pseudo‐MS3 scans in large‐scale proteomics studies is not worthwhile when high‐mass accuracy instrumentation is used.
Journal ArticleDOI
TIMMDC1/C3orf1 Functions as a Membrane-Embedded Mitochondrial Complex I Assembly Factor through Association with the MCIA Complex
TL;DR: A new membrane-embedded CI assembly factor is defined and provided a resource for further analysis of CI biology and Quantitative proteomics demonstrated a role for TIMMDC1 in assembly of membrane- embedded and soluble arms of the complex.
Journal ArticleDOI
Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer
Seth J. Parker,Caroline R. Amendola,Kate E.R. Hollinshead,Qijia Yu,Keisuke Yamamoto,Joel Encarnación-Rosado,Rebecca E. Rose,Madeleine M. LaRue,Albert S. W. Sohn,Doug E. Biancur,Joao A. Paulo,Steven P. Gygi,Drew R. Jones,Huamin Wang,Mark R. Philips,Dafna Bar-Sagi,Joseph D. Mancias,Alec C. Kimmelman +17 more
TL;DR: It is demonstrated that stromal-cancer metabolic niches can form through differential transporter expression, creating unique therapeutic opportunities to target metabolic demands of cancer.
Journal ArticleDOI
The Majority of the Saccharomyces cerevisiae Septin Complexes Do Not Exchange Guanine Nucleotides
TL;DR: It is concluded that bound GTP and GDP play a structural, rather then regulatory, role for the majority of septins in proliferating cells as GTP does for α-tubulin.