Steven P. Gygi

TL;DR: Data show that therapy-induced MHC-I ligands may shape underlying neo-antitumor CD8 T cell responses and should be considered in strategies promoting the efficacy of OV-based cancer immunotherapies.

TL;DR: The findings suggest that the physiological role of substance P released in the striatum is to decrease the activity of the nigrostriatal dopamine pathway.

TL;DR: It is demonstrated that PDCD4 is a cell-cycle regulated protein and that changes in its abundance are sufficient to alter PTX sensitivity in multiple human cancer cell lines, and high levels of PDCD 4 in lung cancer tissues are positively correlated with the longer overall survival time of the examined lung cancer patients with PTX involved adjuvant therapy.

TL;DR: This work finds that ACC2 phosphorylation and hydroxylation occur in an inverse fashion, and identifies an unexpected link between AMPK and PHD3, and a role forPHD3 in acute exercise endurance capacity and skeletal muscle metabolism.