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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
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Journal ArticleDOI
The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects
Ian M. Bird,Susie H. Kim,Devin K. Schweppe,Joana Caetano-Lopes,Alexander G. Robling,Julia F. Charles,Steven P. Gygi,Matthew L. Warman,Matthew L. Warman,Matthew L. Warman,Patrick Smits +10 more
TL;DR: Conditional inactivation of the cis-Golgin GMAP-210 reveals that the skeletal phenotype in achondrogenesis type-1A, which is caused by mutations in GMap-210, is solely due to impaired protein trafficking by chondrocytes.
Posted ContentDOI
Improved Monoisotopic Mass Estimation for Deeper Proteome Coverage
TL;DR: This work presents a performant, open-source, cross-platform algorithm, Monocle, for the rapid reassignment of instrument assigned precursor peaks to monoisotopic peptide assignments and demonstrates that the present algorithm can be integrated into many common proteomics pipelines and provides rapid conversion from multiple data source types.
Patent
Non-affinity based isotope tagged peptides and methods for using the same
TL;DR: In this article, non-affinity based isotope tagged peptides, chemistries for making peptides and methods for using these peptides are described. But the peptide reagents can be used for rapid and quantitative analysis of proteins or protein function.
Journal ArticleDOI
Global proteomics of Ubqln2-based murine models of ALS.
Alexandra M. Whiteley,Miguel A. Prado,Stefanie A. H. de Poot,Joao A. Paulo,Marissa Ashton,Sara L. Dominguez,Martin Weber,Hai Ngu,John Szpyt,Mark P. Jedrychowski,Amy Easton,Steven P. Gygi,Thimo Kurz,Mervyn J. Monteiro,Eric J. Brown,Daniel Finley +15 more
TL;DR: The proteomic landscape of ALS-related Ubqln2 mutants is charted and candidate client proteins that are altered in vivo in disease models and whose degradation is promoted by UBQLN2 are identified.
Journal ArticleDOI
Rixosomal RNA degradation contributes to silencing of Polycomb target genes
Haining Zhou,Chad B Stein,Tiasha A. Shafiq,Gergana Shipkovenska,Marian Kalocsay,Joao A. Paulo,Jiuchun Zhang,Zhenhua Luo,Steven P. Gygi,Karen Adelman,Danesh Moazed +10 more
TL;DR: In this article , the rixosome contributes to silencing of many Polycomb targets in human cells and is enriched at promoters of Polycomb target genes, suggesting that direct recruitment of the RIXosome to chromatin is required for silencing.