Steven P. Gygi

TL;DR: The RNA-processing factor Nudt21 is identified as a novel post-transcriptional regulator of cell fate change using transcription-factor-induced reprogramming as a screening assay and a direct, previously unappreciated link between alternative polyadenylation and chromatin signaling is established.

TL;DR: GCP8 is the first subunit with an interphase-specific role in centrosomal γ-tubulin recruitment and microtubule nucleation and identified various interactors including the novel core subunit GCP8.

TL;DR: An approach involving blood stem cells to discover host factors critical for Plasmodium falciparum infection of red blood cells and identified an essential host receptor for parasite invasion that could provide a target for malaria therapeutics.

TL;DR: This report describes the application of tandem mass spectrometry and database searching to two problems which are prototypical for cancer research and indeed for biomedical research in general, and identifies gel‐separated, low abundance proteins based on amino acid sequence composition following coimmunoprecipitation with the human apoptosis inhibitor protein BclXL.

TL;DR: The structure of a ribosome-channel complex from mammalian endoplasmic reticulum in which the channel has been visualized at 11 A resolution is reported and it is shown that mammalian and bacterial ribosomes-channel complexes have similar architectures.