S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.
Michael W. Susman,Edith P. Karuna,Ryan C. Kunz,Taranjit S. Gujral,Taranjit S. Gujral,Andrea V. Cantú,Shannon S. Choi,Brigette Y Jong,Kyoko Okada,Michael K Scales,Jennie Hum,Linda Hu,Marc W. Kirschner,Ryuichi Nishinakamura,Soichiro Yamada,Diana J. Laird,Li-En Jao,Steven P. Gygi,Michael E. Greenberg,Hsin-Yi Henry Ho,Hsin-Yi Henry Ho +20 more
TL;DR: Findings indicate that Kif26b links Wnt5a-Ror signaling to the control of morphogenetic cell and tissue behaviors in vertebrates and reveal a new role for regulated proteolysis in noncanonical Wnt4/β-catenin-dependent signal transduction.
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Heterochromatic Gene Silencing by Activator Interference and a Transcription Elongation Barrier
TL;DR: Reconstituted budding yeast heterochromatin disrupts transcriptional coactivator recruitment and RNA polymerase elongation, suggesting a conserved principle of heterochromaatin in assembling a specific structure that targets multiple steps to achieve repression.
Journal ArticleDOI
Assigning spectrum-specific P-values to protein identifications by mass spectrometry
Victor Spirin,Alexander Shpunt,Jan Seebacher,Marc Gentzel,Andrej Shevchenko,Steven P. Gygi,Shamil R. Sunyaev +6 more
TL;DR: The proposed statistical approach improves the sensitivity of protein identifications without compromising specificity and is applicable to any search engine which outputs a single score for a peptide-spectrum match.
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Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
Alexandra M. Whiteley,Alexandra M. Whiteley,Miguel A. Prado,Ivan Peng,Alexander R. Abbas,Benjamin Haley,Joao A. Paulo,Mike Reichelt,Anand Kumar Katakam,Meredith Sagolla,Zora Modrusan,Dong Yun Lee,Merone Roose-Girma,Donald S. Kirkpatrick,Brent S. McKenzie,Steven P. Gygi,Daniel Finley,Eric J. Brown +17 more
TL;DR: It is found that UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulation, and its absence leads to suppression of protein synthesis and cell cycle arrest.
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Improved Monoisotopic Mass Estimation for Deeper Proteome Coverage.
TL;DR: This work presents a performant, open-source, cross-platform algorithm, Monocle, for the rapid reassignment of instrument-assigned precursor peaks to monoisotopic peptide assignments and demonstrates that the present algorithm can be integrated into many common proteomic pipelines and provides rapid conversion from multiple data source types.