S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
More filters
Journal ArticleDOI
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor
TL;DR: Four independent mechanisms for uptake of activated EGFR are identified by a combination of receptor mutagenesis and RNA interference approaches.
Journal ArticleDOI
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
John E. Dominy,Yoonjin Lee,Mark P. Jedrychowski,Helen Chim,Michael J. Jurczak,Joao Paulo Camporez,Hai Bin Ruan,Jessica L. Feldman,Kerry A. Pierce,Raul Mostoslavsky,John M. Denu,Clary B. Clish,Xiaoyong Yang,Gerald I. Shulman,Steven P. Gygi,Pere Puigserver +15 more
TL;DR: It is reported that Sirt6 strongly controls PGC-1α acetylation, a key mediator of gluconeogenic gene transcription, and may be therapeutically useful for treating insulin-resistant diabetes.
Journal ArticleDOI
Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
Noga Ron-Harel,Daniel Ditzel Santos,Daniel Ditzel Santos,Jonathan M. Ghergurovich,Peter T. Sage,Peter T. Sage,Anita Reddy,Scott B. Lovitch,Scott B. Lovitch,Noah Dephoure,F. Kyle Satterstrom,Michal Sheffer,Jessica B. Spinelli,Steven P. Gygi,Joshua D. Rabinowitz,Arlene H. Sharpe,Arlene H. Sharpe,Marcia C. Haigis +17 more
TL;DR: It is shown that naive CD4(+) T cell activation induces a unique program of mitochondrial biogenesis and remodeling that generates specialized mitochondria with enhanced one-carbon metabolism that is critical for T-cell activation and survival.
Journal ArticleDOI
RNAi-Dependent and -Independent RNA Turnover Mechanisms Contribute to Heterochromatic Gene Silencing
TL;DR: It is shown that transgene transcripts at centromeric repeats are processed into siRNAs and are therefore direct targets of RNAi, and that Cid14, a member of the Trf4/5 family of poly(A) polymerases, has poly( A) polymerase activity that is required for heterochromatic gene silencing.
Patent
Rapid quantitative analysis of proteins or protein function in complex mixtures
Rudolf H Aebersold,Michael H Gelb,Steven P. Gygi,C. Ronald Scott,František Tureček,Scott A. Gerber,Beate Rist +6 more
TL;DR: In this article, the authors employ affinity labeled protein reactive reagents having three portions: an affinity label (A) covalently linked to a protein reactive group (PRG) through a linker group (L), the linker may be differentially isotopically labeled, e.g., by substitution of one or more atoms in linker with a stable isotope thereof.