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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast
TL;DR: In budding yeast, signals generated in response to membrane growth are required for cell cycle progression and delivery of sphingolipids to the plasma membrane could generate signals that control cell growth and the cell cycle.
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An Internal Standard for Assessing Phosphopeptide Recovery from Metal Ion/Oxide Enrichment Strategies.
TL;DR: A peptide internal standard-based assay directed toward sample preparation strategies for mass spectrometry analysis to understand better phosphopeptide recovery from enrichment strategies, applicable to any enrichment protocol in a typical experimental workflow irrespective of sample origin or labeling strategy.
Journal ArticleDOI
ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control
TL;DR: It is shown that ELAC1 is both necessary and sufficient to remove the 2',3'-cyclic phosphate on ANKZF1-cleaved tRNAs to permit CCA re-addition by TRNT1.
Posted ContentDOI
O-GlcNAc regulates gene expression by controlling detained intron splicing
Zhi-Wei Tan,George Q. Fei,Joao A. Paulo,Stanislav Bellaousov,Sara E. S. Martin,Damien Y. Duveau,Craig J. Thomas,Steven P. Gygi,Paul L. Boutz,Suzanne Walker +9 more
TL;DR: It is shown that a ubiquitous post-translational modification called O-GlcNAc, which is thought to integrate signaling pathways as nutrient conditions fluctuate, controls detained intron splicing to tune system-wide gene expression.
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Cdc7-Dbf4 Is a Gene-Specific Regulator of Meiotic Transcription in Yeast
Hsiao-Chi Lo,Ryan C. Kunz,Xiangyu Chen,Allison Marullo,Steven P. Gygi,Nancy M. Hollingsworth +5 more
TL;DR: This work reveals another role for Cdc7 in meiosis as a gene-specific regulator of the global transcription factor, Ndt80, which is required for exit from pachytene and entry into the meiotic divisions in budding yeast.