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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P
Kostja Renko,Janine Martitz,Sandra Hybsier,Bjoern Heynisch,Linn Voss,Robert A. Everley,Steven P. Gygi,Mette Stoedter,Monika Wisniewska,Josef Köhrle,Vadim N. Gladyshev,Lutz Schomburg +11 more
TL;DR: The findings suggest that the interfering activity of aminoglycosides on selenoprotein biosynthesis can be severe, but depend on the Se status, and other parameters likely including age and general health.
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ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-Elevated Melanomas
Chi Luo,Eduardo Balsa,Ajith J. Thomas,Maximilian Hatting,Mark P. Jedrychowski,Steven P. Gygi,Hans R. Widlund,Pere Puigserver +7 more
TL;DR: ERRα, a druggable protein, mediates the bioenergetic effects in melanomas defined by high PGC1α expression, suggesting a rational means for therapeutic targeting of this particularly aggressive melanoma subtype.
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Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young).
Helge Ræder,Mette Vesterhus,Mette Vesterhus,Mette Vesterhus,Abdelfattah El Ouaamari,Joao A. Paulo,Fiona E. McAllister,Chong Wee Liew,Jiang Hu,Dan Kawamori,Anders Molven,Steven P. Gygi,Pål R. Njølstad,C. Ronald Kahn,Rohit N. Kulkarni +14 more
TL;DR: This murine model of human CEL-MODY diabetes did not detect mutation-specific endocrine or exocrine pancreatic phenotypes, in response to altered diets or exposure to cerulein, and there were no detectable mutation- specific differences in serum amylase, islet hormones or the extent of pancreatic tissue inflammation.
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Mycobacterium tuberculosis Prokaryotic Ubiquitin-like Protein-deconjugating Enzyme Is an Unusual Aspartate Amidase
Kristin E. Burns,Fiona E. McAllister,Carsten Schwerdtfeger,Julian Mintseris,Francisca A. Cerda-Maira,Elke E. Noens,Matthias Wilmanns,Stevan R. Hubbard,Francesco D. Melandri,Huib Ovaa,Steven P. Gygi,K. Heran Darwin +11 more
TL;DR: This work suggests that Asp-95 functions either as a direct nucleophile forming a unique anhydride intermediate or is part of a catalytic center that includes polarized water as the nucleophile in the active site of Dop.
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Blood biomarkers in a mouse model of CADASIL
Vincent Primo,Mark Graham,Alexander A. Bigger-Allen,Joel M. Chick,Carolina Ospina,Yakeel T. Quiroz,Jan Manent,Steven P. Gygi,Francisco Lopera,Patricia A. D'Amore,Joseph F. Arboleda-Velasquez +10 more
TL;DR: Measurements of plasma endostatin, HTRA1 and N3ECD, along with VSMC quantification in retinal arteries, may serve as surrogate endpoints for assessing efficacy in preclinical therapeutic studies of CADASIL using mice.