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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
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Journal ArticleDOI
Large-Scale Proteomic Characterization of Melanoma Expressed Proteins Reveals Nestin and Vimentin as Biomarkers That Can Potentially Distinguish Melanoma Subtypes
Veneta Qendro,Deborah H. Lundgren,Karim Rezaul,Forrest Mahony,Nicholas Ferrell,Andrew Bi,Ardian Latifi,Daniyal Chowdhury,Steven P. Gygi,Wilhelm Haas,Lori L. Wilson,Michael Murphy,David K. Han +12 more
TL;DR: Validation of nestin and vimentin using 40 melanoma samples revealed pattern of protein expression can help predict melanoma aggressiveness in different subgroups of melanoma.
Journal ArticleDOI
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Zachary J. Hauseman,Edward P. Harvey,Catherine E. Newman,Thomas E. Wales,Joel C. Bucci,Julian Mintseris,Devin K. Schweppe,Liron David,Liron David,Lixin Fan,Danny Cohen,Henry D. Herce,Rida Mourtada,Yael Ben-Nun,Noah B. Bloch,Scott B. Hansen,Hao Wu,Hao Wu,Steven P. Gygi,John R. Engen,Loren D. Walensky +20 more
TL;DR: The production and characterization of a full-length BAXO that recapitulates physiologic BAX activation and reveals structural requirements for the elusive execution phase of mitochondrial apoptosis is reported.
Journal ArticleDOI
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity
Mark P. Jedrychowski,Gina Z. Lu,John Szpyt,Marco Mariotti,Ryan Garrity,Joao A. Paulo,Devin K. Schweppe,Dina Laznik-Bogoslavski,Lawrence Kazak,Michael P. Murphy,Vadim N. Gladyshev,Steven P. Gygi,Edward T. Chouchani,Bruce M. Spiegelman +13 more
TL;DR: The existence of facultative protein selenation, which correlates with impacts on thermogenic adipocyte function and presumably other biological processes as well, is revealed by a mass spectrometric method to interrogate incorporation of selenium into proteins.
Journal ArticleDOI
Proteomics Identifies Multipotent and Low Oncogenic Risk Stem Cells of the Spleen
Francisco J. Dieguez-Acuna,Shohta Kodama,Shohta Kodama,Yoshiaki Okubo,Ana C. Paz,Steven P. Gygi,Denise L. Faustman +6 more
TL;DR: Proteomic and functional analyses reveals that naturally occurring CD45- stem cells of the spleen are the first-ever candidates for naturally occurring population of embryonic and iPS cells with low oncogenic risk and low likelihood of malignant transformation.
Patent
Systems, methods and kits for characterizing phosphoproteomes
TL;DR: In this article, the authors provide systems, software, methods and kits for detecting and quantifying phosphorylatable polypeptides and/or acetylated polypepticides in complex mixtures, such as a lysate of a cell or cellular compartment.